Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

Breast cancer progression involves multiple genetic events, which can activate dominant-
acting oncogenes and disrupt the function of specific tumor suppressor genes. This article …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the
maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression …

Histone post-transcriptional modifications play essential roles in regulation of all DNA
related processes. Among them, histone ubiquitination has been discovered for more than …

Recently, many of the enzymes responsible for the addition and removal of ubiquitin from
the histones H2A and H2B have been identified and characterized. From these studies, it …

Critical cellular processes are regulated, in part, by maintaining the appropriate intracellular
levels of proteins. Whereas de novo protein synthesis is a comparatively slow process …

Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an
increased risk of breast and ovarian cancers. BRCA1 participates in the cellular DNA …

The RING finger proteins HdmX and Hdm2 share significant structural and functional
similarity. Hdm2 is a member of the RING finger family of ubiquitin-protein ligases E3 and …

Homologous recombination has been recognized in recent years to be an important DNA
repair pathway in mammalian cells, for such damage as chromosomal double-strand …