In Silico Tools and Approaches for the Prediction of Functional and Structural Effects of Single-Nucleotide Polymorphisms on Proteins: An Expert Review
Single-nucleotide polymorphisms (SNPs) are single-base variants that contribute to human
biological variation and pathogenesis of many human diseases. Among all SNP types …
biological variation and pathogenesis of many human diseases. Among all SNP types …
Structure-based virtual screening to discover potential lead molecules for the SARS-CoV-2 main protease
The COVID-19 disease is caused by a new strain of the coronavirus family (SARS-CoV-2),
and it has affected at present millions of people all over the world. The indispensable role of …
and it has affected at present millions of people all over the world. The indispensable role of …
[PDF][PDF] Corona virus drugs–a brief overview of past, present and future
SH Basha - Journal of PeerScientist, 2020 - peerscientist.com
A novel coronavirus (CoV), SARS-CoV-2 surfaced in late 2019 in Wuhan, China. SARS-CoV-
2, unlike previously identified coronaviruses responsible for severe acute respiratory …
2, unlike previously identified coronaviruses responsible for severe acute respiratory …
Rhapsody: predicting the pathogenicity of human missense variants
Motivation The biological effects of human missense variants have been studied
experimentally for decades but predicting their effects in clinical molecular diagnostics …
experimentally for decades but predicting their effects in clinical molecular diagnostics …
In-silico anti-inflammatory potential of guaiane dimers from Xylopia vielana targeting COX-2
Natural products of herbal origin are prodigious to display diverse pharmacological
activities. In the present study, five guaiane-type sesquiterpene dimers, xylopidimers A− E (1 …
activities. In the present study, five guaiane-type sesquiterpene dimers, xylopidimers A− E (1 …
Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide and In Vitro Evaluation of Its Antiproliferative and Proapoptotic Effects on Cervical Cancer
This work is aimed at investigating the expression levels of inducible nitric oxide synthase
(iNOS) in cervical cancer and identifying a potential iNOS inhibitor. The data mining studies …
(iNOS) in cervical cancer and identifying a potential iNOS inhibitor. The data mining studies …
Computational SNP analysis and molecular simulation revealed the most deleterious missense variants in the NBD1 domain of human ABCA1 transporter
The ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound exporter protein
involved in regulating serum HDL level by exporting cholesterol and phospholipids to load …
involved in regulating serum HDL level by exporting cholesterol and phospholipids to load …
In Silico Approaches for Investigating the Binding Propensity of Apigenin and Luteolin Against Class I HDAC Isoforms
Aim: Aberrant activity of class I histone deacetylases (HDACs) has strong implications for
various cancers. Targeting these HDACs with synthetic HDAC inhibitors has shown …
various cancers. Targeting these HDACs with synthetic HDAC inhibitors has shown …
Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid …
Abstract TDP-43 is an RNA/DNA-binding protein which is also implicated in the
pathogenesis of amyotrophic lateral sclerosis (ALS) disease. TDP-43's cytoplasmic mis …
pathogenesis of amyotrophic lateral sclerosis (ALS) disease. TDP-43's cytoplasmic mis …
A spectroscopic and computational intervention of interaction of lysozyme with 6-mercaptopurine
In the present work, biophysical insight into the binding interactions of the protein, hen egg
white (HEW) lysozyme (Lyz) with an anticancer drug, 6-mercaptopurine (6-MP)‚was …
white (HEW) lysozyme (Lyz) with an anticancer drug, 6-mercaptopurine (6-MP)‚was …