Regulation of transmembrane signaling by phase separation

LB Case, JA Ditlev, MK Rosen - Annual review of biophysics, 2019 - annualreviews.org
Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …

Eph receptors and ephrins in cancer progression

EB Pasquale - Nature Reviews Cancer, 2024 - nature.com
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

Transmembrane coupling of liquid-like protein condensates

Y Lee, S Park, F Yuan, CC Hayden, L Wang… - Nature …, 2023 - nature.com
Liquid-liquid phase separation of proteins occurs on both surfaces of cellular membranes
during diverse physiological processes. In vitro reconstitution could provide insight into the …

Receptor tyrosine kinase activation: From the ligand perspective

R Trenker, N Jura - Current opinion in cell biology, 2020 - Elsevier
Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which
relatively conserved intracellular kinase domains are coupled to divergent extracellular …

Eph receptor signalling: from catalytic to non-catalytic functions

LY Liang, O Patel, PW Janes, JM Murphy, IS Lucet - Oncogene, 2019 - nature.com
Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …

Emerging applications of nanotechnology for controlling cell‐surface receptor clustering

K Zhang, H Gao, R Deng, J Li - … Chemie International Edition, 2019 - Wiley Online Library
The spatial organization of cell‐surface receptors plays an important role in defining cell
fate. Recently, the development of strategies for the direct regulation of receptor clustering …

New insights into the molecular mechanisms of axon guidance receptor regulation and signaling

Y Zang, K Chaudhari, GJ Bashaw - Current topics in developmental …, 2021 - Elsevier
As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

Membrane nanodomains modulate formin condensation for actin remodeling in Arabidopsis innate immune responses

Z Ma, Y Sun, X Zhu, L Yang, X Chen, Y Miao - The Plant Cell, 2022 - academic.oup.com
The assembly of macromolecules on the plasma membrane concentrates cell surface
biomolecules into nanometer-to micrometer-scale clusters (nano-or microdomains) that help …

Phase separation enhances probability of receptor signalling and drug targeting

JE Ladbury, CC Lin, KM Suen - Trends in Biochemical Sciences, 2023 - cell.com
The probability of a given receptor tyrosine kinase (RTK) triggering a defined cellular
outcome is low because of the promiscuous nature of signalling, the randomness of …

[HTML][HTML] The emerging role of receptor tyrosine kinase phase separation in cancer

CC Lin, KM Suen, J Lidster, JE Ladbury - Trends in Cell Biology, 2024 - cell.com
Receptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function
and drives important cellular outcomes which, when dysregulated, can lead to malignant …