Regulation of transmembrane signaling by phase separation
Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …
initiate signal transduction in response to environmental cues. Extracellular ligand …
Eph receptors and ephrins in cancer progression
EB Pasquale - Nature Reviews Cancer, 2024 - nature.com
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …
make up the 'Eph system') in cancer development and progression has been accumulating …
Transmembrane coupling of liquid-like protein condensates
Liquid-liquid phase separation of proteins occurs on both surfaces of cellular membranes
during diverse physiological processes. In vitro reconstitution could provide insight into the …
during diverse physiological processes. In vitro reconstitution could provide insight into the …
Receptor tyrosine kinase activation: From the ligand perspective
Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which
relatively conserved intracellular kinase domains are coupled to divergent extracellular …
relatively conserved intracellular kinase domains are coupled to divergent extracellular …
Eph receptor signalling: from catalytic to non-catalytic functions
Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …
Emerging applications of nanotechnology for controlling cell‐surface receptor clustering
The spatial organization of cell‐surface receptors plays an important role in defining cell
fate. Recently, the development of strategies for the direct regulation of receptor clustering …
fate. Recently, the development of strategies for the direct regulation of receptor clustering …
New insights into the molecular mechanisms of axon guidance receptor regulation and signaling
As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …
toward their synaptic targets to form functional neural circuits. During this highly dynamic …
Membrane nanodomains modulate formin condensation for actin remodeling in Arabidopsis innate immune responses
The assembly of macromolecules on the plasma membrane concentrates cell surface
biomolecules into nanometer-to micrometer-scale clusters (nano-or microdomains) that help …
biomolecules into nanometer-to micrometer-scale clusters (nano-or microdomains) that help …
Phase separation enhances probability of receptor signalling and drug targeting
JE Ladbury, CC Lin, KM Suen - Trends in Biochemical Sciences, 2023 - cell.com
The probability of a given receptor tyrosine kinase (RTK) triggering a defined cellular
outcome is low because of the promiscuous nature of signalling, the randomness of …
outcome is low because of the promiscuous nature of signalling, the randomness of …
[HTML][HTML] The emerging role of receptor tyrosine kinase phase separation in cancer
CC Lin, KM Suen, J Lidster, JE Ladbury - Trends in Cell Biology, 2024 - cell.com
Receptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function
and drives important cellular outcomes which, when dysregulated, can lead to malignant …
and drives important cellular outcomes which, when dysregulated, can lead to malignant …