Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations

LF Yang, M Ling, N Kacherovsky, SH Pun - Chemical Science, 2023 - pubs.rsc.org
Aptamers are single-stranded nucleic acids that bind and recognize targets much like
antibodies. Recently, aptamers have garnered increased interest due to their unique …

Metal sensing by DNA

W Zhou, R Saran, J Liu - Chemical reviews, 2017 - ACS Publications
Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …

Critical evaluation of aptamer binding for biosensor designs

Y Zhao, K Yavari, J Liu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Over the last three decades, numerous aptamer-based biosensors have been reported. The
basis of these sensors is the selective binding of target analytes by aptamers. In the last few …

Recent advances in the development of electrochemical aptasensors for detection of heavy metals in food

L Wang, X Peng, H Fu, C Huang, Y Li, Z Liu - Biosensors and Bioelectronics, 2020 - Elsevier
Heavy metal contamination in environment and food has attracted intensive attention from
the public since it poses serious threats to ecological system and human health. Traditional …

Rationally engineered nucleic acid architectures for biosensing applications

M Xiao, W Lai, T Man, B Chang, L Li… - Chemical …, 2019 - ACS Publications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Synthesis, assembly, and applications of hybrid nanostructures for biosensing

S Zhang, R Geryak, J Geldmeier, S Kim… - Chemical …, 2017 - ACS Publications
The robust, sensitive, and selective detection of targeted biomolecules in their native
environment by prospective nanostructures holds much promise for real-time, accurate, and …

Functional DNA sensors integrated with nucleic acid signal amplification strategies for non-nucleic acid targets detection

Y Zhu, J Wu, Q Zhou - Biosensors and Bioelectronics, 2023 - Elsevier
In addition to carrying and transmitting genetic material, some DNA molecules have specific
binding ability or catalytic function. DNA with this special function is collectively referred to as …

Aptamer-based biosensors for biomedical diagnostics

W Zhou, PJJ Huang, J Ding, J Liu - Analyst, 2014 - pubs.rsc.org
Aptamers are single-stranded nucleic acids that selectively bind to target molecules. Most
aptamers are obtained through a combinatorial biology technique called SELEX. Since …

Functional nucleic acid sensors

J Liu, Z Cao, Y Lu - Chemical reviews, 2009 - ACS Publications
Sensors are devices that respond to physical or chemical stimuli and produce detectable
signals. 1r4 They are a critical extension of human perception of the world in many aspects …

Aptamer-based biosensors

S Song, L Wang, J Li, C Fan, J Zhao - TrAC Trends in Analytical Chemistry, 2008 - Elsevier
Nucleic-acid aptamers have attracted intense interest and found wide applications in a
range of areas. In this review, we summarize recent advances in the development of …