Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …

The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

Objective Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused
by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a …

We report sequencing-based whole-genome association analyses to evaluate the impact of
rare and founder variants on stature in 6,307 individuals on the island of Sardinia. We …

Objective: To describe the characteristics of untreated and recombinant insulin-like growth
factor 1 (IGF-1)-treated patients with the Laron syndrome (LS) as seen in our clinic over a …

Relationships of growth, metabolism, reproduction, and body size to the biological process
of aging and longevity have been studied for decades and various unifying “theories of …

The discovery of a growth hormone receptor antagonist (GHA) was initially established via
expression of mutated GH genes in transgenic mice. Following this discovery, development …

The growth hormone (GH)-insulin-like growth factor-1 (IGF1) signaling pathway emerged in
recent years as a key determinant of aging and longevity. Disruption of this network in …

The cell types of the pars tuberalis (PT) are the follicular cells, the pars distalis cells and the
so-called PT-specific cells. The latter are distinct endocrine cells displaying melatonin …

Laron syndrome (LS) is a rare genetic endocrinopathy that results from mutation of the
growth hormone receptor (GH-R) gene and is typically associated with dwarfism and …