Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Introduction: Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful
methodology to study protein dynamics, protein folding, protein-protein interactions, and …

HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing
antibodies. However, Env structure and organization in its native virion context has eluded …

The function, efficacy, and safety of protein biopharmaceuticals are tied to their three-
dimensional structure. The analysis and verification of this higher-order structure are critical …

Assessing the functional outcome of protein interactions in structural terms is a goal of
structural biology, however most techniques have a limited capacity for making structure …

All processes that occur within living organisms are intimately linked to biological
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …

Hydrogen deuterium exchange mass spectrometry (HDX-MS) is becoming part of the
standard repertoire of techniques used by molecular biologists to investigate protein …

Autophagy mediates the degradation of damaged proteins, organelles and pathogens, and
plays a key role in health and disease. Thus, the identification of new mechanisms involved …

Kinase inhibitors are effective cancer therapies, but resistance often limits clinical efficacy.
Despite the cataloging of numerous resistance mutations, our understanding of kinase …

This article reviews the analytical aspects of measuring hydrogen exchange by mass
spectrometry (HX MS). We describe the nature of analytical selectivity in hydrogen …