Abstract Nav1. 5, the pore forming α-subunit of the voltage-dependent cardiac Na+ channel,
is an integral membrane protein involved in the initiation and conduction of action potentials …

Marked QT prolongation and torsades de pointes can occur not only in the congenital long
QT syndromes (LQTSs) but also as a consequence of environmental stimuli, notably …

Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral
to metastasis (eg, proliferation, motility, secretion, and invasion), although their contribution …

Background—The mechanism of ECG changes and arrhythmogenesis in Brugada
syndrome (BS) patients is unknown. Methods and Results—A BS patient without clinically …

The gene SCN5A encodes the main cardiac sodium channel Na V 1.5. This channel
predominates the cardiac sodium current, I Na, which underlies the fast upstroke of the …

Brugada syndrome is a heritable channelopathy characterized by a peculiar
electrocardiogram (ECG) pattern and increased risk of cardiac arrhythmias and sudden …

The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of
investigators with a wide range of research interests, but all attempting to correlate drug …

Background—Reduced cardiac sodium current slows conduction and renders the heart
susceptible to ventricular fibrillation. Loss of function mutations in SCN5A, encoding the …

The molecular clock mechanism underlies circadian rhythms and is defined by a
transcription-translation feedback loop. Bmal1 encodes a core molecular clock transcription …

Based on recent findings, an increased late sodium current (INa, late) plays an important
pathophysiological role in cardiac diseases, including rhythm disorders. The article first …