[HTML][HTML] TREM-1 modulation strategies for sepsis
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition
receptor, which can be upregulated in inflammatory diseases as an amplifier of immune …
receptor, which can be upregulated in inflammatory diseases as an amplifier of immune …
[HTML][HTML] Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies
V Theobald, FCF Schmitt, CS Middel, L Gaissmaier… - Critical Care, 2024 - Springer
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor
and plays a critical role in the immune response. TREM-1 activation leads to the production …
and plays a critical role in the immune response. TREM-1 activation leads to the production …
[HTML][HTML] TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury
WJ Zhong, J Zhang, JX Duan, CY Zhang… - Journal of Translational …, 2023 - Springer
Background Necroptosis of macrophages is a necessary element in reinforcing
intrapulmonary inflammation during acute lung injury (ALI). However, the molecular …
intrapulmonary inflammation during acute lung injury (ALI). However, the molecular …
[HTML][HTML] The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes
Summary Peptidoglycan recognition protein 1 (PGLYRP1) is a pattern-recognition protein
that mediates antibacterial actions and innate immune responses. Its expression and role in …
that mediates antibacterial actions and innate immune responses. Its expression and role in …
Thymopentin plays a key role in restoring the function of macrophages to alleviate the sepsis process
Z Wen, H Li, C Zhou, L Chen, L Zhang, Y Chen… - International …, 2024 - Elsevier
Immune dysfunction is one of the leading causes of death of sepsis. How to regulate host
immune functions to improve prognoses of septic patients has always been a clinical focus …
immune functions to improve prognoses of septic patients has always been a clinical focus …
[HTML][HTML] N-terminal peptide of PGLYRP1/Tag7 is a novel ligand for TREM-1 receptor
TN Sharapova, OK Ivanova, EA Romanova… - International Journal of …, 2022 - mdpi.com
An investigation of innate immunity receptors sheds light on the mechanisms of inflammation
and associated immune reactions. One of the key immune regulators is the TREM-1 …
and associated immune reactions. One of the key immune regulators is the TREM-1 …
[HTML][HTML] Short peptides of innate immunity protein tag7 inhibit the production of cytokines in cfa-induced arthritis
GB Telegin, AS Chernov, AN Minakov… - International Journal of …, 2022 - mdpi.com
The pathogenesis of autoimmune arthritis is a hot topic in current research. The main focus
of this work was to study cytokines released in CFA-induced arthritis in ICR mice as well as …
of this work was to study cytokines released in CFA-induced arthritis in ICR mice as well as …
[HTML][HTML] CCR5/CXCR3 antagonist TAK-779 prevents diffuse alveolar damage of the lung in the murine model of the acute respiratory distress syndrome
AS Chernov, MV Rodionov, VA Kazakov… - Frontiers in …, 2024 - frontiersin.org
Introduction: The acute respiratory distress syndrome (ARDS), secondary to viral
pneumonitis, is one of the main causes of high mortality in patients with COVID-19 (novel …
pneumonitis, is one of the main causes of high mortality in patients with COVID-19 (novel …
[HTML][HTML] Serum proteomics hint at an early T-cell response and modulation of SARS-CoV-2-related pathogenic pathways in COVID-19-ARDS treated with Ruxolitinib
S Völkel, TS Tarawneh, L Sacher, AM Bhagwat… - Frontiers in …, 2023 - frontiersin.org
Background Acute respiratory distress syndrome (ARDS) in corona virus disease 19 (COVID-
19) is triggered by hyperinflammation, thus providing a rationale for immunosuppressive …
19) is triggered by hyperinflammation, thus providing a rationale for immunosuppressive …
Cytokine Receptors in Development, Homeostasis and Disease
AC Ward - International Journal of Molecular Sciences, 2023 - mdpi.com
This Special Issue represents a collective celebration of the cytokine receptor superfamily
and the myriad of functions mediated by these important molecules in development and …
and the myriad of functions mediated by these important molecules in development and …