Synapse development requires differentiation of presynaptic neurotransmitter release sites
and postsynaptic receptive apparatus coordinated by synapse organizing proteins. In …

The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …

Neurexins are recognized as key organizers of synapses that are essential for normal brain
function. However, it is unclear whether neurexins are fundamental building blocks of all …

Intellectual disability (ID) is a measurable phenotypic consequence of genetic and
environmental factors. In this study, we prospectively assessed the diagnostic yield of …

Brain function relies on fast and precisely timed synaptic vesicle (SV) release at active zones
(AZs). Efficacy of SV release depends on distance from SV to Ca2+ channel, but molecular …

Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

The neurexin family of cell adhesion proteins consists of three members in vertebrates and
has homologs in several invertebrate species. In mammals, each neurexin gene encodes an …

Clarin-1, a tetraspan-like membrane protein defective in Usher syndrome type IIIA (USH3A),
is essential for hair bundle morphogenesis in auditory hair cells. We report a new synaptic …

Neuroligins are evolutionarily conserved postsynaptic cell adhesion molecules that interact
with presynaptic neurexins. Neurons express multiple neuroligin isoforms that are targeted …

Neurons are highly polarized cells with a single axon and multiple dendrites derived from
the cell body to form tightly associated pre-and postsynaptic compartments. As the …