Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Cognitive decline in Parkinson's disease is related to cholinergic system degeneration,
which can be assessed in vivo using structural MRI markers of basal forebrain volume and …

The integrity of the cholinergic system plays a central role in cognitive decline both in normal
aging and neurological disorders including Alzheimer's disease and vascular cognitive …

The medial frontal cortex has been linked to voluntary action, but an explanation of why
decisions to act emerge at particular points in time has been lacking. We show that, in …

Progress in scientific disciplines is accompanied by standardization of terminology. Network
neuroscience, at the level of macroscale organization of the brain, is beginning to confront …

Cholinergic changes play a fundamental role in the natural history of dementia with Lewy
bodies and Lewy body disease in general. Despite important achievements in the field of …

Background The mainstay of therapy for many neurodegenerative dementias still relies on
acetylcholinesterase inhibitors (AChEI); however, there is debate on various aspects of such …

Cognitive impairment is a well‐recognized and debilitating symptom of Parkinson's disease
(PD). Degradation in the cortical cholinergic system is thought to be a key contributor. Both …