Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …

In anaphase, any unresolved DNA entanglements between the segregating sister
chromatids can give rise to chromatin bridges. To prevent genome instability, chromatin …

Transcription-blocking DNA lesions (TBLs) in genomic DNA are triggered by a wide variety
of DNA-damaging agents. Such lesions cause stalling of elongating RNA polymerase II …

Nucleotide excision repair (NER) is the most versatile DNA repair pathway, which can
remove diverse bulky DNA lesions destabilizing a DNA duplex. NER defects cause several …

Abstract Mutations in the Cockayne Syndrome group B (CSB) gene cause cancer in mice,
but premature aging and severe neurodevelopmental defects in humans. CSB, a member of …

Guanine-rich DNA sequences are known to fold into secondary structures called G-
quadruplexes (G4s), which can form from either individual DNA strands (intra-molecular) or …

Decades of research have identified genetic and environmental factors involved in age-
related neurodegenerative diseases and, to a lesser extent, neuropsychiatric disorders …

Mitochondria-nuclear coadaptation has been central to eukaryotic evolution. The dynamic
dialogue between the two compartments within the context of multiorganellar interactions is …

Conspectus The ability of genomic DNA to adopt non-canonical secondary structures known
as G-quadruplexes (G4s) under physiological conditions has been recognized for its …