Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease

T Yasuhara, N Matsukawa, K Hara, G Yu… - Journal of …, 2006 - Soc Neuroscience
Neural stem cells (NSCs) possess high potencies of self-renewal and neuronal
differentiation. We explored here whether transplantation of human NSCs cloned by v-myc …

Cognitive dysfunction and depression in Parkinson's disease: what can be learned from rodent models?

HS Lindgren, SB Dunnett - European Journal of Neuroscience, 2012 - Wiley Online Library
Parkinson's disease (PD) has for decades been considered a pure motor disorder and its
cardinal motor symptoms have been attributed to the loss of dopaminergic (DAergic) …

Therapeutic Potential of Embodied Cognition for Clinical Psychotherapies: From Theory to Practice

JMB Fugate, SL Macrine… - Cognitive Therapy and …, 2024 - Springer
Background This paper examines cognitive and body-based therapies through the lens of
embodiment, framing treatments as constructed experiences shaped by individuals' …

Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: motor impairments identify extent of dopamine depletion at three different lesion sites

A Heuer, GA Smith, MJ Lelos, EL Lane… - Behavioural brain …, 2012 - Elsevier
The unilateral 6-hydroxydopamine mouse lesion models of Parkinson's disease have
received increasing attention in recent years, but comparison of the different lesion models …

The Corridor Task: a simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the …

E Dowd, C Monville, EM Torres, SB Dunnett - Brain research bulletin, 2005 - Elsevier
In this experiment, we report a novel drug-free behavioural test of lateralised neglect which
is sensitive to unilateral dopamine-denervating lesions and subsequent graft-derived striatal …

The 6-OHDA mouse model of Parkinson's disease–terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain …

V Bagga, SB Dunnett, RA Fricker - Behavioural brain research, 2015 - Elsevier
Abstract Unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway
produce side-biased motor impairments that reflect the motor deficits seen in Parkinson's …

Lentivector‐mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model

E Dowd, C Monville, EM Torres… - European Journal of …, 2005 - Wiley Online Library
Although viral vector‐mediated delivery of glial cell‐line derived neurotrophic factor (GDNF)
to the brain has considerable potential as a neuroprotective strategy in Parkinson's disease …

Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: predicting l-DOPA-induced dyskinesia

GA Smith, A Heuer, SB Dunnett, EL Lane - Behavioural brain research, 2012 - Elsevier
In the 6-hydroxydopamine (6-OHDA) lesioned rodent the location of the lesion produces
significantly different behavioural phenotypes, responses to the dopamine precursor l-3, 4 …

Primary tissue for cellular brain repair in Parkinson's disease: Promise, problems and the potential of biomaterials

N Moriarty, CL Parish, E Dowd - European Journal of …, 2019 - Wiley Online Library
The dopamine precursor, levodopa, remains the “gold standard” treatment for Parkinson's
disease, and, although it provides superlative efficacy in the early stages of the disease, its …

Portable microstimulator for chronic deep brain stimulation in freely moving rats

C Forni, O Mainard, C Melon, D Goguenheim… - Journal of neuroscience …, 2012 - Elsevier
In the last decades, deep brain stimulation (DBS) has been widely used as a functional
surgical strategy for the treatment of a variety of neurological and psychiatric disorders …