Parkinson disease (PD) is the most common neurodegenerative movement disorder. In
Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 …

Execution of fundamental cellular functions demands regulated protein folding homeostasis.
Endoplasmic reticulum (ER) is an active organelle existing to implement this function by …

Arsenic (As) contamination affects hundreds of millions of people globally. Although the
number of patients with chronic As exposure is large, the symptoms and long-term clinical …

Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Among the various respiratory viruses infecting human beings, coronaviruses are important
pathogens, which usually infect the upper respiratory tract, where they are mainly associated …

Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

In humans, viral infections of the respiratory tract are a leading cause of morbidity and
mortality worldwide. Several recognized respiratory viral agents have a neuroinvasive …

The close apposition between endoplasmic reticulum (ER) and mitochondria represents a
key platform, capable to regulate different fundamental cellular pathways. Among these, Ca …

α-Synuclein has a central role in Parkinson disease, but its physiological function and the
mechanism leading to neuronal degeneration remain unknown. Because recent studies …

Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells
to respond and adapt to constantly changing environments. In multicellular organisms, it …