Mitochondrial-derived peptides in energy metabolism
TL Merry, A Chan, JST Woodhead… - American Journal …, 2020 - journals.physiology.org
Mitochondrial-derived peptides (MDPs) are small bioactive peptides encoded by short open-
reading frames (sORF) in mitochondrial DNA that do not necessarily have traditional …
reading frames (sORF) in mitochondrial DNA that do not necessarily have traditional …
Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases
Humanin (HN) is a small mitochondrial-derived cytoprotective polypeptide encoded by
mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells …
mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells …
Mitochondria, immunosenescence and inflammaging: a role for mitokines?
M Conte, M Martucci, A Chiariello, C Franceschi… - Seminars in …, 2020 - Springer
A global reshaping of the immune responses occurs with ageing, indicated as
immunosenescence, where mitochondria and mitochondrial metabolism play an important …
immunosenescence, where mitochondria and mitochondrial metabolism play an important …
[HTML][HTML] The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
Humanin is a member of a new family of peptides that are encoded by short open reading
frames within the mitochondrial genome. It is conserved in animals and is both …
frames within the mitochondrial genome. It is conserved in animals and is both …
Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications
Mitochondrial-derived peptides (MDPs) are a novel class of bioactive microproteins that
modify cell metabolism. The the eight MDPs that been characterized (eg, humanin, MOTS-c …
modify cell metabolism. The the eight MDPs that been characterized (eg, humanin, MOTS-c …
Humanin and its pathophysiological roles in aging: A systematic review
D Coradduzza, A Congiargiu, Z Chen, S Cruciani… - Biology, 2023 - mdpi.com
Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …
number of potential therapeutic applications for various age-related diseases. It plays an …
Extending human healthspan and longevity: a symposium report
LM DeVito, N Barzilai, AM Cuervo… - Annals of the New …, 2022 - Wiley Online Library
For many years, it was believed that the aging process was inevitable and that age‐related
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …
High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men
JST Woodhead, RF D'Souza… - Journal of applied …, 2020 - journals.physiology.org
Humanin is a small regulatory peptide encoded within the 16S ribosomal RNA gene (MT-
RNR2) of the mitochondrial genome that has cellular cyto-and metabolo-protective …
RNR2) of the mitochondrial genome that has cellular cyto-and metabolo-protective …
The role of mitochondria-derived peptides in cardiovascular diseases and their potential as therapeutic targets
SA Dabravolski, NG Nikiforov, AV Starodubova… - International Journal of …, 2021 - mdpi.com
Mitochondria-derived peptides (MDPs) are small peptides hidden in the mitochondrial DNA,
maintaining mitochondrial function and protecting cells under different stresses. Currently …
maintaining mitochondrial function and protecting cells under different stresses. Currently …
The mitochondrial‐derived peptide MOTS‐c is a regulator of plasma metabolites and enhances insulin sensitivity
MOTS‐c is an exercise mimetic and improves insulin sensitivity in aged and diet‐induced
obese mice. Although plasma markers are good markers for the metabolic condition …
obese mice. Although plasma markers are good markers for the metabolic condition …