How can machine learning and multiscale modeling benefit ocular drug development?

N Wang, Y Zhang, W Wang, Z Ye, H Chen, G Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …

Stellar transits across a magnetized accretion torus as a mechanism for plasmoid ejection

P Suková, M Zajaček, V Witzany… - The Astrophysical …, 2021 - iopscience.iop.org
The close neighborhood of a supermassive black hole contains not only the accreting gas
and dust but also stellar-sized objects, such as late-type and early-type stars and compact …

Derivation of the variants of the Burgers model using a thermodynamic approach and appealing to the concept of evolving natural configurations

J Málek, KR Rajagopal, K Tůma - Fluids, 2018 - mdpi.com
Viscoelastic rate-type fluid models involving the stress and frame-indifferent time derivatives
of second order, like those in Burgers' model, are used to describe the complicated …

Stabilization of a smoothed finite element semi-implicit coupling scheme for viscoelastic fluid–structure interaction

T He - Journal of Non-Newtonian Fluid Mechanics, 2021 - Elsevier
We propose in this work a stabilization approach for semi-implicit coupling of viscoelastic
fluid–structure interaction (VFSI) using the cell-based smoothed finite element method (CS …

Coupling of a Nonlinear Structure with Sloshing

MY Abdollahzadeh Jamalabadi - Mathematical Problems in …, 2023 - Wiley Online Library
In this paper the role of solid nonlinearity on the fluid–structure interaction (FSI) is studied.
First a simple mass‐spring‐damper system with a third‐degree spring is coupled with a …

Fluid–structure numerical solver for axi-symmetric flows with Navier's slip interface condition between the viscoelastic solid and the Navier–Stokes fluid: Effects of …

J Fara, J Hron, J Málek, KR Rajagopal… - International Journal of …, 2024 - Elsevier
Flows of an incompressible Navier–Stokes fluid are frequently assumed to take place in
domains whose boundaries are rigid and that the fluid adheres to them, ie there is the “no …

Finite amplitude stability of internal steady flows of the Giesekus viscoelastic rate-type fluid

M Dostalík, V Průša, K Tůma - Entropy, 2019 - mdpi.com
Using a Lyapunov type functional constructed on the basis of thermodynamical arguments,
we investigate the finite amplitude stability of internal steady flows of viscoelastic fluids …

In-vivo characterization of scleral rigidity in myopic eyes using fundus-pulsation optical coherence elastography

Z Gong, KD Bojikian, A Chen, PP Chen… - Biomedical Optics …, 2024 - opg.optica.org
The sclera plays an important role in the structural integrity of the eye. However, as myopia
progresses, the elongation of the eyeball exerts stretching forces on the posterior sclera …

On diffusive variants of some classical viscoelastic rate-type models

M Dostalík, V Průša, T Skřivan - AIP Conference Proceedings, 2019 - pubs.aip.org
We present a thermodynamically based approach to the design of models for viscoelastic
fluids with stress diffusion effect. In particular, we show how to add a stress diffusion term to …

Back of the eye anatomy and physiology: Impact on product development

CG Wilson - Ophthalmic Product Development: From Bench to …, 2022 - Springer
Abstract Treatment of ocular tissues is attempted to remedy infection, inflammatory disease
and the sequelae of pathological systemic changes such as diabetes and degenerative …