Turning the tide on Alzheimer's disease: Modulation of γ-secretase
JE Luo, YM Li - Cell & Bioscience, 2022 - Springer
Alzheimer's disease (AD) is the most common type of neurodegenerative disorder. Amyloid-
beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the …
beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the …
Modulation of notch signaling by small-molecular compounds and its potential in anticancer studies
Simple Summary The dysregulation of Notch signaling plays an important role in cancer
development. Numerous attempts are made to modulate Notch signaling for positive …
development. Numerous attempts are made to modulate Notch signaling for positive …
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity
G Güner, M Aßfalg, K Zhao, T Dreyer… - EMBO Molecular …, 2022 - embopress.org
Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also
linked to chronic diseases. Despite its physiological and medical importance, the regulation …
linked to chronic diseases. Despite its physiological and medical importance, the regulation …
Affinity probes based on small-molecule inhibitors for tumor imaging
X Yi, Z Wang, X Hu, A Yu - Frontiers in Oncology, 2022 - frontiersin.org
Methods for molecular imaging of target areas, including optical imaging, radionuclide
imaging, magnetic resonance imaging and other imaging technologies, are helpful for the …
imaging, magnetic resonance imaging and other imaging technologies, are helpful for the …
Application of fluorocarbon nanoparticles of 131I-fulvestrant as a targeted radiation drug for endocrine therapy on human breast cancer
L Zhi, C Cheng, L Jing, P Zhi-Ping, Y Lu, T Yan… - Journal of …, 2024 - Springer
Background Breast cancer is the most prevalent malignant tumor among women, with
hormone receptor-positive cases constituting 70%. Fulvestrant, an antagonist for these …
hormone receptor-positive cases constituting 70%. Fulvestrant, an antagonist for these …
Natural Human Immune Response Identifies An Unnatural Oncology Target for Immunotherapy
MC Glassy - Handbook of Cancer and Immunology, 2023 - Springer
The intelligence of the natural human immune response can be exploited to recognize
antigenic targets useful in oncology. A component of this response, pritumumab, is a natural …
antigenic targets useful in oncology. A component of this response, pritumumab, is a natural …
Mechanism of Gamma-Secretase Modulators: From Tools to Therapeutics
J Luo - 2022 - search.proquest.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
memory loss and cognitive decline. Currently there are no treatments which delay or stop …
memory loss and cognitive decline. Currently there are no treatments which delay or stop …