Turning the tide on Alzheimer's disease: Modulation of γ-secretase

JE Luo, YM Li - Cell & Bioscience, 2022 - Springer
Alzheimer's disease (AD) is the most common type of neurodegenerative disorder. Amyloid-
beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the …

Modulation of notch signaling by small-molecular compounds and its potential in anticancer studies

A Czerwonka, J Kałafut, M Nees - Cancers, 2023 - mdpi.com
Simple Summary The dysregulation of Notch signaling plays an important role in cancer
development. Numerous attempts are made to modulate Notch signaling for positive …

Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity

G Güner, M Aßfalg, K Zhao, T Dreyer… - EMBO Molecular …, 2022 - embopress.org
Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also
linked to chronic diseases. Despite its physiological and medical importance, the regulation …

Affinity probes based on small-molecule inhibitors for tumor imaging

X Yi, Z Wang, X Hu, A Yu - Frontiers in Oncology, 2022 - frontiersin.org
Methods for molecular imaging of target areas, including optical imaging, radionuclide
imaging, magnetic resonance imaging and other imaging technologies, are helpful for the …

Application of fluorocarbon nanoparticles of 131I-fulvestrant as a targeted radiation drug for endocrine therapy on human breast cancer

L Zhi, C Cheng, L Jing, P Zhi-Ping, Y Lu, T Yan… - Journal of …, 2024 - Springer
Background Breast cancer is the most prevalent malignant tumor among women, with
hormone receptor-positive cases constituting 70%. Fulvestrant, an antagonist for these …

Natural Human Immune Response Identifies An Unnatural Oncology Target for Immunotherapy

MC Glassy - Handbook of Cancer and Immunology, 2023 - Springer
The intelligence of the natural human immune response can be exploited to recognize
antigenic targets useful in oncology. A component of this response, pritumumab, is a natural …

Mechanism of Gamma-Secretase Modulators: From Tools to Therapeutics

J Luo - 2022 - search.proquest.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
memory loss and cognitive decline. Currently there are no treatments which delay or stop …