Lipid nanoparticles as delivery systems for RNA-based vaccines
BN Aldosari, IM Alfagih, AS Almurshedi - Pharmaceutics, 2021 - mdpi.com
There has been increased interest in the development of RNA-based vaccines for protection
against various infectious diseases and also for cancer immunotherapies. Rapid and cost …
against various infectious diseases and also for cancer immunotherapies. Rapid and cost …
Three decades of messenger RNA vaccine development
R Verbeke, I Lentacker, SC De Smedt, H Dewitte - Nano Today, 2019 - Elsevier
In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …
for vaccination. In the following decades, an improved understanding of the mRNA …
Eliciting B cell immunity against infectious diseases using nanovaccines
A Singh - Nature nanotechnology, 2021 - nature.com
Infectious diseases, including the coronavirus disease 2019 (COVID-19) pandemic that has
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …
Control of polymeric nanoparticle size to improve therapeutic delivery
As nanoparticle (NP)-mediated drug delivery research continues to expand, understanding
parameters that govern NP interactions with the biological environment becomes …
parameters that govern NP interactions with the biological environment becomes …
[HTML][HTML] Follicular dendritic cells: dynamic antigen libraries
BA Heesters, RC Myers, MC Carroll - Nature Reviews Immunology, 2014 - nature.com
Follicular dendritic cells (FDCs) are essential for high-affinity antibody production and for the
development of B cell memory. Historically, FDCs have been characterized as' …
development of B cell memory. Historically, FDCs have been characterized as' …
Shape and size-dependent immune response to antigen-carrying nanoparticles
S Kumar, AC Anselmo, A Banerjee… - Journal of Controlled …, 2015 - Elsevier
The immune system has evolved to recognize and respond to a wide variety of pathogens
and produce distinct immune responses against diverse pathogenic structures. Despite …
and produce distinct immune responses against diverse pathogenic structures. Despite …
B cell follicles and antigen encounters of the third kind
JG Cyster - Nature immunology, 2010 - nature.com
Defining where and in what form lymphocytes encounter antigen is fundamental to
understanding how immune responses occur. Although knowledge of the recognition of …
understanding how immune responses occur. Although knowledge of the recognition of …
pH-Responsive Poly(d,l-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response
In the quest to treat intracellular infectious diseases and virus infection, nanoparticles (NPs)
have been considered to be efficient tools for inducing potent immune responses …
have been considered to be efficient tools for inducing potent immune responses …
Designing inorganic nanomaterials for vaccines and immunotherapies
KL Hess, IL Medintz, CM Jewell - Nano Today, 2019 - Elsevier
Vaccines and immunotherapies have changed the face of health care. Biomaterials offer the
ability to improve upon these medical technologies through increased control of the types …
ability to improve upon these medical technologies through increased control of the types …
DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling
O Tal, HY Lim, I Gurevich, I Milo, Z Shipony… - Journal of Experimental …, 2011 - rupress.org
Dendritic cells (DCs) must travel through lymphatics to carry skin antigens into lymph nodes.
The processes controlling their mobilization and migration have not been completely …
The processes controlling their mobilization and migration have not been completely …