Lipid nanoparticles as delivery systems for RNA-based vaccines

BN Aldosari, IM Alfagih, AS Almurshedi - Pharmaceutics, 2021 - mdpi.com
There has been increased interest in the development of RNA-based vaccines for protection
against various infectious diseases and also for cancer immunotherapies. Rapid and cost …

Three decades of messenger RNA vaccine development

R Verbeke, I Lentacker, SC De Smedt, H Dewitte - Nano Today, 2019 - Elsevier
In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …

Eliciting B cell immunity against infectious diseases using nanovaccines

A Singh - Nature nanotechnology, 2021 - nature.com
Infectious diseases, including the coronavirus disease 2019 (COVID-19) pandemic that has
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …

Control of polymeric nanoparticle size to improve therapeutic delivery

JW Hickey, JL Santos, JM Williford, HQ Mao - Journal of Controlled …, 2015 - Elsevier
As nanoparticle (NP)-mediated drug delivery research continues to expand, understanding
parameters that govern NP interactions with the biological environment becomes …

[HTML][HTML] Follicular dendritic cells: dynamic antigen libraries

BA Heesters, RC Myers, MC Carroll - Nature Reviews Immunology, 2014 - nature.com
Follicular dendritic cells (FDCs) are essential for high-affinity antibody production and for the
development of B cell memory. Historically, FDCs have been characterized as' …

Shape and size-dependent immune response to antigen-carrying nanoparticles

S Kumar, AC Anselmo, A Banerjee… - Journal of Controlled …, 2015 - Elsevier
The immune system has evolved to recognize and respond to a wide variety of pathogens
and produce distinct immune responses against diverse pathogenic structures. Despite …

B cell follicles and antigen encounters of the third kind

JG Cyster - Nature immunology, 2010 - nature.com
Defining where and in what form lymphocytes encounter antigen is fundamental to
understanding how immune responses occur. Although knowledge of the recognition of …

pH-Responsive Poly(d,l-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response

Q Liu, X Chen, J Jia, W Zhang, T Yang, L Wang, G Ma - ACS nano, 2015 - ACS Publications
In the quest to treat intracellular infectious diseases and virus infection, nanoparticles (NPs)
have been considered to be efficient tools for inducing potent immune responses …

Designing inorganic nanomaterials for vaccines and immunotherapies

KL Hess, IL Medintz, CM Jewell - Nano Today, 2019 - Elsevier
Vaccines and immunotherapies have changed the face of health care. Biomaterials offer the
ability to improve upon these medical technologies through increased control of the types …

DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling

O Tal, HY Lim, I Gurevich, I Milo, Z Shipony… - Journal of Experimental …, 2011 - rupress.org
Dendritic cells (DCs) must travel through lymphatics to carry skin antigens into lymph nodes.
The processes controlling their mobilization and migration have not been completely …