Metals to combat antimicrobial resistance

A Frei, AD Verderosa, AG Elliott, J Zuegg… - Nature Reviews …, 2023 - nature.com
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Coordination metal complexes with Schiff bases: Useful pharmacophores with comprehensive biological applications

P Ghanghas, A Choudhary, D Kumar… - Inorganic Chemistry …, 2021 - Elsevier
Antibiotic-resistant infections on the health care system and the population have put a
burden on economic and adequate health. There is an urgent need to develop new …

Noble metals in medicine: Latest advances

S Medici, M Peana, VM Nurchi, JI Lachowicz… - Coordination Chemistry …, 2015 - Elsevier
History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

Metal complexes, an untapped source of antibiotic potential?

A Frei - Antibiotics, 2020 - mdpi.com
With the widespread rise of antimicrobial resistance, most traditional sources for new drug
compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal …

Anti-cancer palladium complexes: a focus on PdX 2 L 2, palladacycles and related complexes

AR Kapdi, IJS Fairlamb - Chemical Society Reviews, 2014 - pubs.rsc.org
Much success has been achieved with platinum-based chemotherapeutic agents, ie through
interactions with DNA. The long-term application of Pt complexes is thwarted by issues …

New mononuclear and binuclear Cu (II), Co (II), Ni (II), and Zn (II) thiosemicarbazone complexes with potential biological activity: antimicrobial and molecular docking …

A Gaber, MS Refat, AAM Belal, IM El-Deen, N Hassan… - Molecules, 2021 - mdpi.com
Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+,
and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining …

Coordination compounds of pyrazolone‐based ligand: Design, characterization, biological evaluation, antitumor efficiency, and DNA binding evaluation supported by …

SA Ibrahim, A Ragab… - Applied Organometallic …, 2022 - Wiley Online Library
Abstract Cu (II), Ni (II), Mn (II), and Cr (III) chelates of the organic ligand named 3‐(furan‐2‐
yl)‐5‐oxo‐N, 1‐diphenyl‐4, 5‐dihydro‐1H‐pyrazole‐4‐carbothioamide ligand (abbreviated …

Comprehensive review on tumour active palladium compounds and structure–activity relationships

MN Alam, F Huq - Coordination Chemistry Reviews, 2016 - Elsevier
This article provides a comprehensive review of palladium compounds that have been
evaluated for anticancer activity in vivo or in vitro from the era of discovery of cisplatin up to …

Studies on DNA binding properties of new Schiff base ligands using spectroscopic, electrochemical and computational methods: Influence of substitutions on DNA …

A Jamshidvand, M Sahihi, V Mirkhani… - Journal of Molecular …, 2018 - Elsevier
In this work, five new Schiff base ligands were synthesized and characterized by 1 H NMR,
13 C NMR, FT-IR, UV–Vis and elemental analysis (CHN). L 1, L 2 and L 3, were derived …

Antibacterial and anticorrosion behavior of bioactive complexes of selected transition metal ions with new 2‐acetylpyridine Schiff base

RG Deghadi, AE Elsharkawy… - Applied …, 2022 - Wiley Online Library
Successful preparation of Schiff base 4‐(4‐aminophenoxy)‐N‐(1‐(pyridin‐2‐yl) ethylidene)
aniline derived from refluxing of 4, 4‐oxydianniline with 2‐acetylpyridine within 2 h in 1: 1 …