Poly (disulfide) s: from synthesis to drug delivery

R Zhang, T Nie, Y Fang, H Huang, J Wu - Biomacromolecules, 2021 - ACS Publications
Bioresponsive polymers have been widely used in drug delivery because of their
degradability. For example, poly (disulfide) s with repeating disulfide bonds in the main …

Recent progress of redox-responsive polymeric nanomaterials for controlled release

PH Hsu, A Almutairi - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Redox-responsive polymeric nanomaterials (PNMs) have been attractive research targets
for drug delivery systems because disturbed levels of redox molecules are associated with …

Mucus‐Inspired Self‐Healing Hydrogels: A Protective Barrier for Cells against Viral Infection

R Bej, CA Stevens, C Nie, K Ludwig… - Advanced …, 2024 - Wiley Online Library
Mucus is a dynamic biological hydrogel, composed primarily of the glycoprotein mucin,
exhibits unique biophysical properties and forms a barrier protecting cells against a broad …

Fast-Forming Dissolvable Redox-Responsive Hydrogels: Exploiting the Orthogonality of Thiol–Maleimide and Thiol–Disulfide Exchange Chemistry

I Altinbasak, S Kocak, R Sanyal, A Sanyal - Biomacromolecules, 2022 - ACS Publications
Fast-forming yet easily dissolvable hydrogels (HGs) have potential applications in wound
healing, burn incidences, and delivery of therapeutic agents. Herein, a combination of a thiol …

Redox-Triggered Activation of Heavy-Atom-Free Photosensitizer and Implications in Targeted Photodynamic Therapy

T Banerjee, K Dan, AK Pal, R Bej, A Datta… - ACS Macro …, 2023 - ACS Publications
A strategy for a redox-activatable heavy-atom-free photosensitizer (PS) based on thiolated
naphthalimide has been demonstrated. The PS exhibits excellent reactive oxygen species …

Amphiphilic micro‐and nanogels: Combining properties from internal hydrogel networks, solid particles, and micellar aggregates

C Biglione, TMP Neumann‐Tran… - Journal of Polymer …, 2021 - Wiley Online Library
Polymeric micro‐and nanogels are defined by their water‐swollen hydrophilic networks that
can often impart outstanding biocompatibility and high‐colloidal stability. Unfortunately, this …

Strategic chemical synthesis and application of nanocarriers responsive to the tumor microenvironment

Q Pang, Z Xu, T Sun, S Yue, Y Yu, H Lu, M He, X Chen… - Nano Today, 2024 - Elsevier
In contrast to normal tissues and cells, the tumor microenvironment (TME) exhibits distinct
physiological attributes, including elevated concentrations of reactive oxygen species and …

Thiol-and disulfide-based stimulus-responsive soft materials and self-assembling systems

DM Beaupre, RG Weiss - Molecules, 2021 - mdpi.com
Properties and applications of synthetic thiol-and disulfide-based materials, principally
polymers, are reviewed. Emphasis is placed on soft and self-assembling materials in which …

Inhibitors of thiol-mediated uptake

Y Cheng, AT Pham, T Kato, B Lim, D Moreau… - Chemical …, 2021 - pubs.rsc.org
Ellman's reagent has caused substantial confusion and concern as a probe for thiol-
mediated uptake because it is the only established inhibitor available but works neither …

Polymersome Formation by Amphiphilic Polyglycerol-b-polydisulfide-b-polyglycerol and Glutathione-Triggered Intracellular Drug Delivery

R Bej, K Achazi, R Haag, S Ghosh - Biomacromolecules, 2020 - ACS Publications
This article reports the synthesis, spontaneous self-assembly, highly efficient drug
encapsulation, and glutathione (GSH)-triggered intracellular sustained drug delivery of an …