Epigenetic regulation of cellular senescence
J Crouch, M Shvedova, RJRS Thanapaul… - Cells, 2022 - mdpi.com
Senescence is a complex cellular stress response that abolishes proliferative capacity and
generates a unique secretory pattern that is implicated in organismal aging and age-related …
generates a unique secretory pattern that is implicated in organismal aging and age-related …
A common signature of cellular senescence; does it exist?
E Sikora, A Bielak-Zmijewska, G Mosieniak - Ageing research reviews, 2021 - Elsevier
Cellular senescence is a stress response, which can be evoked in all type of somatic cells
by different stimuli. Senescent cells accumulate in the body and participate in aging and …
by different stimuli. Senescent cells accumulate in the body and participate in aging and …
Nuclear morphology is a deep learning biomarker of cellular senescence
Cellular senescence is an important factor in aging and many age-related diseases, but
understanding its role in health is challenging due to the lack of exclusive or universal …
understanding its role in health is challenging due to the lack of exclusive or universal …
[HTML][HTML] SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and
can express a pro-inflammatory, tissue-destructive senescence-associated secretory …
can express a pro-inflammatory, tissue-destructive senescence-associated secretory …
cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
CRR Schmitz, RM Maurmann, FTCR Guma… - Frontiers in …, 2023 - frontiersin.org
Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …
progressive decline of immune responses (immunosenescence). This apparent paradox can …
[HTML][HTML] Impact of senescent cell subtypes on tissue dysfunction and repair: importance and research questions
U Tripathi, A Misra, T Tchkonia, JL Kirkland - Mechanisms of ageing and …, 2021 - Elsevier
Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …
Hallmarks and biomarkers of skin senescence: An updated review of skin senotherapeutics
D Bulbiankova, R Díaz-Puertas, FJ Álvarez-Martínez… - Antioxidants, 2023 - mdpi.com
Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular …
leading to degenerative diseases and an increased probability of death. Cellular …
Nucleolus and nucleolar stress: from cell fate decision to disease development
Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …
The evolution of the hallmarks of aging
M Lemoine - Frontiers in Genetics, 2021 - frontiersin.org
The evolutionary theory of aging has set the foundations for a comprehensive understanding
of aging. The biology of aging has listed and described the “hallmarks of aging,” ie, cellular …
of aging. The biology of aging has listed and described the “hallmarks of aging,” ie, cellular …
Age‐dependent nuclear lipid droplet deposition is a cellular hallmark of aging in Caenorhabditis elegans
K Palikaras, M Mari, C Ploumi, A Princz… - Aging …, 2023 - Wiley Online Library
Aging is the major risk factor for several life‐threatening pathologies and impairs the function
of multiple cellular compartments and organelles. Age‐dependent deterioration of nuclear …
of multiple cellular compartments and organelles. Age‐dependent deterioration of nuclear …