Senescence is a complex cellular stress response that abolishes proliferative capacity and
generates a unique secretory pattern that is implicated in organismal aging and age-related …

Cellular senescence is a stress response, which can be evoked in all type of somatic cells
by different stimuli. Senescent cells accumulate in the body and participate in aging and …

Cellular senescence is an important factor in aging and many age-related diseases, but
understanding its role in health is challenging due to the lack of exclusive or universal …

Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and
can express a pro-inflammatory, tissue-destructive senescence-associated secretory …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …

Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …

Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular …

Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …

The evolutionary theory of aging has set the foundations for a comprehensive understanding
of aging. The biology of aging has listed and described the “hallmarks of aging,” ie, cellular …

Aging is the major risk factor for several life‐threatening pathologies and impairs the function
of multiple cellular compartments and organelles. Age‐dependent deterioration of nuclear …