During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …

Neural stem cells (NSCs) provide promising approaches for investigating embryonic
neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and …

Current imaging approaches limit the ability to perform multi-scale characterization of three-
dimensional (3D) organotypic cultures (organoids) in large numbers. Here, we present an …

The establishment and maintenance of apical‐basal polarity is a fundamental step in brain
development, instructing the organization of neural progenitor cells (NPCs) and the …

During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study human neural development and disease. Especially in the field of Alzheimer's …

Current preclinical studies in drug development utilize high-throughput in vitro screens to
identify drug leads, followed by both in vitro and in vivo models to predict lead candidates' …

Primary and secondary neurulation–processes that form the spinal cord–are incompletely
understood in humans, largely due to the challenge of accessing neurulation-stage embryos …

Neural rosettes develop from the self-organization of differentiating human pluripotent stem
cells. This process mimics the emergence of the embryonic central nervous system …

Leigh syndrome (LS) is a rare, inherited neurometabolic disorder that presents with bilateral
brain lesions caused by defects in the mitochondrial respiratory chain and associated …

Abstract Background Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor
for late-onset Alzheimer's Disease (AD). Although ApoE4 differs from its non-pathological …