Extensive research on the Ras proteins and their functions in cell physiology over the past
30 years has led to numerous insights that have revealed the involvement of Ras not only in …

Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG)
biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized …

We have used mouse embryonic fibroblasts (MEFs) devoid of Ras proteins to illustrate that
they are essential for proliferation and migration, but not for survival, at least in these cells …

Clear cell renal cell carcinomas (ccRCCs) display divergent clinical behaviours. Molecular
markers might improve risk stratification of ccRCC. Here we use, based on genome-wide …

Purpose The purpose of this study was to determine the prognostic role of ten eleven
translocation (TET) family proteins and DNA glycosylase (TDG) in patients with early breast …

Growing evidence indicates that Rab GTPases, key regulators of intracellular transport in
eukaryotic cells, play an important role in cancer. We analysed the deregulation at the …

Stimulation of epidermal growth factor receptor (EGFR) initiates RAS signaling
simultaneously with EGFR internalization. Endocytosed EGFR is then either recycled or …

Dynamic actin remodeling is fundamental to processes such as cell motility, vesicle
trafficking, and cytokinesis. Protein kinase D (PKD) is a serine–threonine kinase known to be …

Background Renal cell carcinoma (RCC) is the tenth most commonly diagnosed cancer in
the United States. While it is usually lethal when metastatic, RCC is successfully treated with …

Although c-Abl and Arg non–receptor tyrosine kinases are well known for driving leukemia
development, their role in solid tumors has not been appreciated until recently …