R-loops as Janus-faced modulators of DNA repair
A Marnef, G Legube - Nature cell biology, 2021 - nature.com
R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …
and genome stability. In addition to their recognized roles in triggering DNA double-strand …
The regulation and functions of the nuclear RNA exosome complex
The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …
The exosome has a central role in several aspects of RNA biogenesis, including RNA …
BRCA2 controls DNA: RNA hybrid level at DSBs by mediating RNase H2 recruitment
DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired,
may lead to genomic instability, cell death and senescence. Damage-induced long non …
may lead to genomic instability, cell death and senescence. Damage-induced long non …
RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity
We have ablated the cellular RNA degradation machinery in differentiated B cells and
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …
Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination
Immunoglobulin heavy chain (IgH) locus-associated G-rich long noncoding RNA (SμGLT) is
important for physiological and pathological B cell DNA recombination. We demonstrate that …
important for physiological and pathological B cell DNA recombination. We demonstrate that …
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
D Papadopoulos, D Solvie, A Baluapuri, T Endres… - Molecular cell, 2022 - cell.com
The MYCN oncoprotein drives the development of numerous neuroendocrine and pediatric
tumors. Here we show that MYCN interacts with the nuclear RNA exosome, a 3′-5 …
tumors. Here we show that MYCN interacts with the nuclear RNA exosome, a 3′-5 …
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
J Domingo-Prim, M Endara-Coll, F Bonath… - Nature …, 2019 - nature.com
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism.
Here we show that the exosome is necessary for the repair of DNA double-strand breaks …
Here we show that the exosome is necessary for the repair of DNA double-strand breaks …
XRN2 links transcription termination to DNA damage and replication stress
JC Morales, P Richard, PL Patidar, EA Motea… - PLoS …, 2016 - journals.plos.org
XRN2 is a 5'-3'exoribonuclease implicated in transcription termination. Here we demonstrate
an unexpected role for XRN2 in the DNA damage response involving resolution of R-loop …
an unexpected role for XRN2 in the DNA damage response involving resolution of R-loop …
The roles of RNA in DNA double-strand break repair
Effective DNA repair is essential for cell survival: a failure to correctly repair damage leads to
the accumulation of mutations and is the driving force for carcinogenesis. Multiple pathways …
the accumulation of mutations and is the driving force for carcinogenesis. Multiple pathways …
[HTML][HTML] New faces of old friends: emerging new roles of RNA-binding proteins in the DNA double-strand break response
JA Klaric, S Wüst, S Panier - Frontiers in molecular biosciences, 2021 - frontiersin.org
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. To protect genomic
stability and ensure cell homeostasis, cells mount a complex signaling-based response that …
stability and ensure cell homeostasis, cells mount a complex signaling-based response that …