Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Small‐fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C
fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes
are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons …

Background Neuropathic pain is common in peripheral neuropathy. Recent genetic studies
have linked pathogenic voltage-gated sodium channel (VGSC) variants to human pain …

Pain is deemed chronic if it lasts more than 12 weeks and can sometimes last a lifetime.
Although some clinical pain syndromes are traced back to specific causes such as traumatic …

Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range
from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on …

Introduction or background Congenital insensitivity to pain (CIP) is caused by extremely rare
Mendelian genetic disorders. CIP individuals demonstrate the unexpectedly severe …

Pain is a significant global health issue, and the current treatment options for pain
management have limitations in terms of effectiveness, side effects, and potential for …

Chronic pain is a global problem affecting up to 20% of the world's population and has a
significant economic, social and personal cost to society. Sensory neurons of the dorsal root …