Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a
non-uniform phenotype and diverse functional activities. Both tumor-associated …

Factor analysis decomposes single-cell gene expression data into a minimal set of gene
programs that correspond to processes executed by cells in a sample. However, matrix …

Single-cell RNA sequencing is the reference technology to characterize the composition of
the tumor microenvironment and to study tumor heterogeneity at high resolution. Here we …

Macrophages represent a key component of the tumor microenvironment (TME) and are
largely associated with poor prognosis. Therapeutic targeting of macrophages has …

Epithelial barriers are programmed for defense and repair but are also the site of long-term
structural remodeling and disease. In general, this paradigm features epithelial stem cells …

Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because
their pro-tumor and immunosuppressive functions are relevant for disease progression and …

The immune system is comprised of both innate and adaptive immune cells, which, in the
context of cancer, collectively function to eliminate tumor cells. However, tumors can actively …

In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …