A local circuit-basis for spatial navigation and memory processes in hippocampal area CA1

T Geiller, JB Priestley, A Losonczy - Current opinion in neurobiology, 2023 - Elsevier
The hippocampus is a multi-stage neural circuit that is critical for memory formation. Its
distinct anatomy has long inspired theories that rely on local interactions between neurons …

Calcium and activity-dependent signaling in the developing cerebral cortex

A Arjun McKinney, R Petrova… - Development, 2022 - journals.biologists.com
Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

Cortico-cortical feedback engages active dendrites in visual cortex

M Fişek, D Herrmann, A Egea-Weiss, M Cloves… - Nature, 2023 - nature.com
Sensory processing in the neocortex requires both feedforward and feedback information
flow between cortical areas. In feedback processing, higher-level representations provide …

A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons

K Xiao, Y Li, RA Chitwood, JC Magee - Science Advances, 2023 - science.org
Behavioral timescale synaptic plasticity (BTSP) is a type of non-Hebbian synaptic plasticity
reported to underlie place field formation. Despite this important function, the molecular …

Dendritic, delayed, stochastic CaMKII activation in behavioural time scale plasticity

A Jain, Y Nakahata, T Pancani, T Watabe, P Rusina… - Nature, 2024 - nature.com
Behavioural time scale plasticity (BTSP) is non-Hebbian plasticity induced by integrating
presynaptic and postsynaptic components separated by a behaviourally relevant time scale …

Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo

DM Virga, S Hamilton, B Osei, A Morgan… - Nature …, 2024 - nature.com
Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake,
and therefore have instructive roles in synaptic function and neuronal response properties …

Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42 toxicity

VL Hewitt, L Miller-Fleming, MJ Twyning… - Life Science …, 2022 - life-science-alliance.org
Mitochondria-ER contact sites (MERCs) orchestrate many important cellular functions
including regulating mitochondrial quality control through mitophagy and mediating …

Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

L Judák, B Chiovini, G Juhász, D Pálfi… - Nature …, 2022 - nature.com
Neuronal plasticity has been shown to be causally linked to coincidence detection through
dendritic spikes (dSpikes). We demonstrate the existence of SPW-R-associated, branch …

The dendritic engram

G Kastellakis, S Tasciotti, I Pandi… - Frontiers in Behavioral …, 2023 - frontiersin.org
Accumulating evidence from a wide range of studies, including behavioral, cellular,
molecular and computational findings, support a key role of dendrites in the encoding and …

Membrane-bound supramolecular nanofiber network stimulates transient receptor potential channels for calcium overload cancer therapy

Z Zhang, X Sun, Y Ding, X Zhang, Y Zhang, T Zhang… - Nano Today, 2023 - Elsevier
Abstract Calcium (Ca 2+) overload therapy is an efficient cancer treatment modality that
increases aberrant cytoplasmic Ca 2+ accumulation and activates mitochondrial apoptotic …