Rational design of cancer nanomedicine: nanoproperty integration and synchronization

Q Sun, Z Zhou, N Qiu, Y Shen - Advanced materials, 2017 - Wiley Online Library
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …

Recent progress in polymer-based platinum drug delivery systems

H Xiao, L Yan, EM Dempsey, W Song, R Qi, W Li… - Progress in Polymer …, 2018 - Elsevier
Platinum drugs comprise of almost 50% of all currently used anticancer drugs. They are now
widely used in the clinical therapy of various solid tumors, including ovarian, head and neck …

Multifaceted roles of copper ions in anticancer nanomedicine

S Yang, Y Song, Y Hu, HJ Chen… - Advanced Healthcare …, 2023 - Wiley Online Library
The significantly increased copper level in tumor tissues and serum indicates the close
association of copper ions with tumor development, making copper ions attractive targets in …

Recent advances in pH/enzyme-responsive polysaccharide-small-molecule drug conjugates as nanotherapeutics

YF Abbasi, H Bera, D Cun, M Yang - Carbohydrate polymers, 2023 - Elsevier
Now-a-days, the polysaccharides are extensively employed for the delivery of small-
molecule drugs ascribed to their excellent biocompatibility, biodegradability and …

Polymeric and small molecule-conjugates of temozolomide as improved therapeutic agents for glioblastoma multiforme

R Jatyan, P Singh, DK Sahel, YG Karthik… - Journal of Controlled …, 2022 - Elsevier
Abstract Temozolomide (TMZ), an imidazotetrazine, is a second-generation DNA alkylating
agent used as a first-line treatment of glioblastoma multiforme (GBM). It was approved by …

Phytochemical based nanomedicines against cancer: current status and future prospects

M Rizwanullah, S Amin, SR Mir, KU Fakhri… - Journal of drug …, 2018 - Taylor & Francis
Cancer continues to be one in all the leading reasons for death worldwide. The mean
cancer survival through standard therapeutic strategies has not been significantly improved …

Bioengineered carboxymethylcellulose–peptide hybrid nanozyme cascade for targeted intracellular biocatalytic–magnetothermal therapy of brain cancer cells

AAP Mansur, SM Carvalho, LCA Oliveira… - Pharmaceutics, 2022 - mdpi.com
Glioblastoma remains the most lethal form of brain cancer, where hybrid nanomaterials
biofunctionalized with polysaccharide peptides offer disruptive strategies relying on …

α-Amylase-and redox-responsive nanoparticles for tumor-targeted drug delivery

Y Li, H Hu, Q Zhou, Y Ao, C Xiao, J Wan… - … applied materials & …, 2017 - ACS Publications
Paclitaxel (PTX) is an effective antineoplastic agent and shows potent antitumor activity
against a wide spectrum of cancers. Yet, the wide clinical use of PTX is limited by its poor …

Design and development of polysaccharide-doxorubicin-peptide bioconjugates for dual synergistic effects of integrin-targeted and cell-penetrating peptides for cancer …

AAP Mansur, SM Carvalho, ZIP Lobato… - Bioconjugate …, 2018 - ACS Publications
Polymer-drug conjugation is an attractive approach for target delivering insoluble and highly
toxic drugs to tumor sites to overcome the side-effects caused by cancer chemotherapy. In …

Rethinking nanoparticulate polymer–drug conjugates for cancer theranostics

Y Wang, H Xia, B Chen, Y Wang - … Reviews: Nanomedicine and …, 2023 - Wiley Online Library
Polymer–drug conjugates (PDCs) fabricated as nanoparticles have hogged the limelight in
cancer theranostics in the past decade. Many researchers have devoted to developing novel …