Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment

DJ Eckert, MK Younes - Journal of Applied Physiology, 2014 - journals.physiology.org
Historically, brief awakenings from sleep (cortical arousals) have been assumed to be vitally
important in restoring airflow and blood-gas disturbances at the end of obstructive sleep …

Effects of opioid, hypnotic and sedating medications on sleep‐disordered breathing in adults with obstructive sleep apnoea

M Mason, CJ Cates, I Smith - Cochrane Database of …, 2015 - cochranelibrary.com
Background Obstructive sleep apnoea (OSA) is a common sleep disorder characterised by
partial or complete upper airway occlusion during sleep, leading to intermittent cessation …

Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold

DJ Eckert, RL Owens, GB Kehlmann… - Clinical …, 2011 - portlandpress.com
Recent insights into sleep apnoea pathogenesis reveal that a low respiratory arousal
threshold (awaken easily) is important for many patients. As most patients experience stable …

The male predisposition to pharyngeal collapse: importance of airway length

A Malhotra, Y Huang, RB Fogel, G Pillar… - American journal of …, 2002 - atsjournals.org
Obstructive sleep apnea is an important disorder because of both its prevalence and its
cardiovascular and neurocognitive sequelae. Despite the fact that male sex is a major risk …

Upper airway collapsibility (Pcrit) and pharyngeal dilator muscle activity are sleep stage dependent

JC Carberry, AS Jordan, DP White, A Wellman… - Sleep, 2016 - academic.oup.com
Abstract Study Objectives: An anatomically narrow/highly collapsible upper airway is the
main cause of obstructive sleep apnea (OSA). Upper airway muscle activity contributes to …

Association of sleep-disordered breathing with postoperative complications

D Hwang, N Shakir, B Limann, C Sison, S Kalra… - Chest, 2008 - Elsevier
Background Obstructive sleep apnea (OSA) is associated with increased perioperative risk,
but the incidence of postoperative complications and the severity of OSA associated with …

Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome

RM Esclamado, MG Glenn, TM McCulloch… - The …, 1989 - Wiley Online Library
A retrospective review of 135 patients surgically treated for obstructive sleep apnea
syndrome (OSAS) from 1982 to 1987 was performed to identify perioperative complications …

Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold

DJ Eckert, A Malhotra, A Wellman, DP White - Sleep, 2014 - academic.oup.com
Abstract Study Objectives: The effect of common sedatives on upper airway physiology and
breathing during sleep in obstructive sleep apnea (OSA) has been minimally studied …

Obstructive sleep apnea in the adult obese patient: implications for airway management

JL Benumof - Journal of clinical anesthesia, 2001 - Elsevier
Obstructive sleep apnea in the adult obese patient may be due, in part, to an increased
amount of pharyngeal tissue. Therefore, there is an increased risk of intubation and …

[HTML][HTML] Comparison of sedation with midazolam and ketamine: effects on airway muscle activity

GB Drummond - British journal of anaesthesia, 1996 - Elsevier
Male patients, aged 27-74 yr, without hypertension or overt cardiovascular disease were
premedicated with temazepam 20 mg orally and allocated randomly to receive sedation with …