[HTML][HTML] Targeting the nucleolus for cancer intervention

JE Quin, JR Devlin, D Cameron, KM Hannan… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The contribution of the nucleolus to cancer is well established with respect to its traditional
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary …

[HTML][HTML] A charge-dependent mechanism is responsible for the dynamic accumulation of proteins inside nucleoli

YR Musinova, EY Kananykhina… - … et Biophysica Acta (BBA …, 2015 - Elsevier
The majority of known nucleolar proteins are freely exchanged between the nucleolus and
the surrounding nucleoplasm. One way proteins are retained in the nucleoli is by the …

A novel signature constructed by RNA-binding protein coding genes to improve overall survival prediction of glioma patients

Z Tu, L Shu, J Li, L Wu, C Tao, M Ye, X Zhu… - Frontiers in Cell and …, 2021 - frontiersin.org
RNA binding proteins (RBPs) have been reported to be involved in cancer malignancy but
related functions in glioma have been less studied. Herein, we screened 14 prognostic RBP …

Interplay between human nucleolar GNL1 and RPS20 is critical to modulate cell proliferation

R Krishnan, N Boddapati, S Mahalingam - Scientific Reports, 2018 - nature.com
Human Guanine nucleotide binding protein like 1 (GNL1) belongs to HSR1_MMR1
subfamily of nucleolar GTPases. Here, we report for the first time that GNL1 promotes cell …

Mycoplasma gallisepticum MGA_0676 is a membrane-associated cytotoxic nuclease with a staphylococcal nuclease region essential for nuclear translocation and …

J Xu, D Teng, F Jiang, Y Zhang, SA El-Ashram… - Applied microbiology …, 2015 - Springer
Mycoplasma gallisepticum can infect a wide variety of birds including the commercial
poultry. M. gallisepticum MGA_0676 is a putative lipoprotein, which is similar to bacterial …

Guanine Nucleotide-Binding Protein-Like 1 (GNL1) binds RNA G-quadruplex structures in genes associated with Parkinson's disease

MA Turcotte, JM Garant, H Cossette-Roberge… - RNA biology, 2021 - Taylor & Francis
RNAs are highly regulated at the post-transcriptional level in neurodegenerative diseases
and just a few mutations can significantly affect the fate of neuronal cells. To date, the impact …

Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21 CIP1 signaling cascade

R Krishnan, M Murugiah, NP Lakshmi… - Molecular biology of …, 2020 - Am Soc Cell Biol
Human guanine nucleotide binding protein like 1 (GNL1) is an evolutionary conserved
putative nucleolar GTPase belonging to the HSR1_MMR1 subfamily of GTPases. GNL1 was …

GNL3L is a Nucleo-Cytoplasmic shuttling Protein: Role in cell cycle regulation

IJ Thoompumkal, MRK Subba Rao, A Kumaraswamy… - PLoS one, 2015 - journals.plos.org
GNL3L is an evolutionarily conserved high molecular weight GTP binding nucleolar protein
belonging to HSR1-MMR1 subfamily of GTPases. The present investigation reveals that …

An epigenome-wide association study of inflammatory response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network

N Yusuf, B Hidalgo, MR Irvin, J Sha, D Zhi… - …, 2017 - Taylor & Francis
Aim: Fenofibrate, a PPAR-α inhibitor used for treating dyslipidemia, has well-documented
anti-inflammatory effects that vary between individuals. While DNA sequence variation …

Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent …

YH Liu, YJ Chen, HH Wu, TY Wang, FJ Tsai - Ophthalmology, 2014 - Elsevier
Objective To investigate whether a conserved HLA class I region influenced the
development of Graves' ophthalmopathy (GO) in patients with Graves' disease (GD) in a …