Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway
has substantial implications for the fidelity of genome maintenance. DNA interstrand …

DNA interstrand crosslinks (ICLs), highly toxic lesions that covalently link the Watson and
Crick strands of the double helix, are repaired by a complex, replication-coupled pathway in …

INTRODUCTION DNA damage encountered during DNA replication represents a major
challenge to the integrity of the genome. Because replicative polymerases are unable to …

DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork
progression. ICL accumulation results in growth arrest and cell death—particularly in cell …

Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks.
Numerous factors involved in crosslink repair have been identified, and mutations in their …

DNA repair pathways are crucial to maintain the integrity of our genome and prevent genetic
diseases such as cancer. There are many different types of DNA damage and specific DNA …

DNA replication errors generate complex chromosomal rearrangements and thereby
contribute to tumorigenesis and other human diseases. One mechanism that triggers these …

Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of
unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps …

DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and
transcription and therefore are extremely cytotoxic. In metazoans, a major pathway of ICL …

DNA interstrand cross‐links (ICL s) are repaired in S phase by a complex, multistep
mechanism involving translesion DNA polymerases. After replication forks collide with an …