Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
4D printing and stimuli-responsive materials in biomedical aspects
Abstract Three-dimensional (3D) printing has revolutionized the world manufacturing
production. In biomedical applications, however, 3D printed constructs fell short of …
production. In biomedical applications, however, 3D printed constructs fell short of …
VEGF-A in cardiomyocytes and heart diseases
M Braile, S Marcella, L Cristinziano… - International Journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …
Engineered in vitro disease models
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …
human disease or to develop new and improved therapies or diagnostics. Although great …
[HTML][HTML] Cell maturation: Hallmarks, triggers, and manipulation
JR Alvarez-Dominguez, DA Melton - Cell, 2022 - cell.com
How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …
While maturity is usually deemed a terminal fate, it may be more helpful to consider …
Mechanosensitive mechanisms in transcriptional regulation
Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro–correlation between contraction force and electrophysiology
MC Ribeiro, LG Tertoolen, JA Guadix, M Bellin… - Biomaterials, 2015 - Elsevier
Cardiomyocytes from human pluripotent stem cells (hPSC-CM) have many potential
applications in disease modelling and drug target discovery but their phenotypic similarity to …
applications in disease modelling and drug target discovery but their phenotypic similarity to …
Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) grown in
engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart …
engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart …
Contact guidance for cardiac tissue engineering using 3D bioprinted gelatin patterned hydrogel
Here, we have developed a 3D bioprinted microchanneled gelatin hydrogel that promotes
human mesenchymal stem cell (hMSC) myocardial commitment and supports native …
human mesenchymal stem cell (hMSC) myocardial commitment and supports native …