A cell integrates various signals through a network of biomolecules that crosstalk to
synergistically regulate the replication, transcription, translation and other metabolic …

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …

Sirtuins are protein deacetylases that play a protective role in cardiovascular diseases
(CVDs), as well as many other diseases. Absence of sirtuins can lead to hyperacetylation of …

Functional genomics is an emerging field focused on elucidating the functions of genes or
proteins, which can help solve challenges related to reliable cancer therapy. One of the …

The biological complexity cannot be captured by genes or proteins alone. The protein
posttranslational modifications (PTMs) impart functional diversity to the proteome and …

Background Experimental studies have demonstrated that both the extracellular vasculature
or microenvironment and intracellular molecular network (eg, epidermal growth factor …

Posttranslational modifications (PTMs) of proteins are covalent functional groups at specific
amino acid residues that extend the regulatory function of the proteins. The modifications …

Humans and pathogenic bacteria have been at war since antiquity. The antibiotics aim to kill
the pathogen but the intense selection pressure induces the development of antibiotic …

Posttranslational modifications (PTMs) affect fundamental cellular functions of the human
malaria parasite Plasmodium falciparum, including regulation of protein stability …