Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …

Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is
much different from the early paradigm in which IL-2 is central for protective immune …

Exposure to inhaled allergens generates T helper 2 (Th2) CD4+ T cells that contribute to
episodes of inflammation associated with asthma. Little is known about allergen-specific Th2 …

Proliferation of Ag-specific T cells is central to the development of protective immunity. The
concomitant stimulation of the TCR and CD28 programs resting T cells to IL-2-driven clonal …

Listeria monocytogenes infection generates T helper 1 (Th1) effector memory cells and CC
chemokine receptor 7 (CCR7)+ cells resembling central memory cells. We tracked …

The effects of inflammatory cytokines on naive T cells have been studied using MHC
protein/peptide complexes on microspheres, thus avoiding the use of APCs whose functions …

IL-2 is a potent T cell growth factor that for many years was assumed to amplify lymphocyte
responses in vivo. Accordingly, IL-2 has been used clinically to enhance T cell immunity in …

Evidence has accumulated that cytokines have a fundamental role in the differentiation of
memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell …

Micro RNA s (mi RNA s) are a newly recognized class of regulatory genes which repress the
expression of protein‐coding genes. Numerous studies have uncovered a complex role for …

It is thought that immunity depends on naïve CD4 T cells that proliferate in response to
microbial antigens,,,, differentiate into memory cells that produce anti-microbial …