First contact: the role of respiratory cilia in host-pathogen interactions in the airways

LE Kuek, RJ Lee - … Journal of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

Primary cilia in glial cells: An oasis in the journey to overcoming neurodegenerative diseases

SM Ki, HS Jeong, JE Lee - Frontiers in Neuroscience, 2021 - frontiersin.org
Many neurodegenerative diseases have been associated with defects in primary cilia, which
are cellular organelles involved in diverse cellular processes and homeostasis. Several …

ALS-linked C9orf72–SMCR8 complex is a negative regulator of primary ciliogenesis

D Tang, K Zheng, J Zhu, X Jin, H Bao… - Proceedings of the …, 2023 - National Acad Sciences
Massive GGGGCC (G4C2) repeat expansion in C9orf72 and the resulting loss of C9orf72
function are the key features of~ 50% of inherited amyotrophic lateral sclerosis and …

Primary cilia shape hallmarks of health and aging

DF Silva, C Cavadas - Trends in Molecular Medicine, 2023 - cell.com
Primary cilia are specialized organelles that sense changes in extracellular milieu, and their
malfunction is responsible for several disorders (ciliopathies). Increasing evidence shows …

Airway ciliated cells in adult lung homeostasis and COPD

LMG Petit, R Belgacemi, J Ancel… - European …, 2023 - Eur Respiratory Soc
Cilia are organelles emanating from the cell surface, consisting of an axoneme of
microtubules that extends from a basal body derived from the centrioles. They are either …

An integrated analysis of mRNAs, lncRNAs, and miRNAs based on weighted gene co-expression network analysis involved in bovine endometritis

N Sheybani, MR Bakhtiarizadeh, A Salehi - Scientific reports, 2021 - nature.com
In dairy cattle, endometritis is a severe infectious disease that occurs following parturition. It
is clear that genetic factors are involved in the etiology of endometritis, however, the …

Primary cilia suppress Ripk3-mediated necroptosis

E Kieckhöfer, GG Slaats, LK Ebert, MC Albert… - Cell death …, 2022 - nature.com
Cilia are sensory organelles that project from the surface of almost all cells.
Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases …

Can cilia provide an entry gateway for SARS-CoV-2 to human ciliated cells?

R Buqaileh, H Saternos, S Ley… - Physiological …, 2021 - journals.physiology.org
A worldwide coronavirus pandemic is in full swing and, at the time of writing, there are only
few treatments that have been successful in clinical trials, but no effective antiviral treatment …

[PDF][PDF] Role of ciliary protein intraflagellar transport protein 88 in the regulation of cartilage thickness and osteoarthritis development in mice

CR Coveney, L Zhu, J Miotla‐Zarebska… - Arthritis & …, 2022 - Wiley Online Library
Objective Mechanical and biologic cues drive cellular signaling in cartilage development,
health, and disease. Primary cilia proteins, which are implicated in the transduction of …

Mice with lung airway ciliopathy develop persistent Mycobacterium abscessus lung infection and have a proinflammatory lung phenotype associated with decreased …

A Nava, AC Hahn, TH Wu, TF Byrd - Frontiers in Immunology, 2022 - frontiersin.org
Introduction Human pulmonary infection with non-tuberculous mycobacteria (NTM) such as
Mycobacterium abscessus (Mabs) occurs in seemingly immunocompetent patients with …