Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …

The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of
malaria, and kills more than one million African children annually. Here we report an …

For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been
a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal …

Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

Drug candidates that form covalent linkages with their target proteins have been
underexplored compared with the conventional counterparts that modulate biological …

In the past few years, inflammation has emerged as a major driving force of atherosclerotic
lesion development. It is now well-established that from early lesion to vulnerable plaque …

Most of the examples of protein translocation across a membrane (such as the import of
classical secretory proteins into the endoplasmic reticulum, import of proteins into …

Macrophage migration inhibitory (MIF) factor is an immunoregulatory cytokine whose effect
on arresting random immune cell movement was recognized several decades ago. Despite …

The vast majority of extracellular proteins are exported from mammalian cells by the
endoplasmic reticulum/Golgi‐dependent secretory pathway. For poorly understood reasons …