Regulation of bacterial virulence by Csr (Rsm) systems

CA Vakulskas, AH Potts, P Babitzke… - Microbiology and …, 2015 - Am Soc Microbiol
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke - Microbiology spectrum, 2018 - Am Soc Microbiol
The sequence-specific RNA binding protein CsrA is employed by diverse bacteria in the
posttranscriptional regulation of gene expression. Its binding interactions with RNA have …

Assembly landscape for the bacterial large ribosomal subunit

K Sheng, N Li, JN Rabuck-Gibbons, X Dong… - Nature …, 2023 - nature.com
Assembly of ribosomes in bacteria is highly efficient, taking~ 2-3 min, but this makes the
abundance of assembly intermediates very low, which is a challenge for mechanistic …

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

AH Potts, CA Vakulskas, A Pannuri, H Yakhnin… - Nature …, 2017 - nature.com
CsrA is a post-transcriptional regulatory protein that is widely distributed among bacteria.
This protein influences bacterial lifestyle decisions by binding to the 5′ untranslated and/or …

Secondary structure across the bacterial transcriptome reveals versatile roles in mRNA regulation and function

C Del Campo, A Bartholomäus, I Fedyunin… - PLoS …, 2015 - journals.plos.org
Messenger RNA acts as an informational molecule between DNA and translating
ribosomes. Emerging evidence places mRNA in central cellular processes beyond its major …

Diverse mechanisms and circuitry for global regulation by the RNA-binding protein CsrA

C Pourciau, YJ Lai, M Gorelik, P Babitzke… - Frontiers in …, 2020 - frontiersin.org
The carbon storage regulator (Csr) or repressor of stationary phase metabolites (Rsm)
system of Gammaproteobacteria is among the most complex and best-studied …

[HTML][HTML] Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors

H Song, Y Li, Y Wang - Engineering Microbiology, 2023 - Elsevier
The signal transduction system of microorganisms helps them adapt to changes in their
complex living environment. Two-component system (TCS) is a representative signal …

Genomic targets and features of BarA-UvrY (-SirA) signal transduction systems

TR Zere, CA Vakulskas, Y Leng, A Pannuri, AH Potts… - PLoS …, 2015 - journals.plos.org
The two-component signal transduction system BarA-UvrY of Escherichia coli and its
orthologs globally regulate metabolism, motility, biofilm formation, stress resistance …

Bacterial versatility requires DEAD-box RNA helicases

P Redder, S Hausmann, V Khemici… - FEMS microbiology …, 2015 - academic.oup.com
RNA helicases of the DEAD-box and DEAH-box families are important players in many
processes involving RNA molecules. These proteins can modify RNA secondary structures …

Antagonistic control of the turnover pathway for the global regulatory sRNA CsrB by the CsrA and CsrD proteins

CA Vakulskas, Y Leng, H Abe, T Amaki… - Nucleic acids …, 2016 - academic.oup.com
The widely conserved protein CsrA (carbon storage regulator A) globally regulates bacterial
gene expression at the post-transcriptional level. In many species, CsrA activity is governed …