Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …

In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to
be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a …

Irisin protects the cardiovascular system against vascular diseases. However, its role in
chronic kidney disease (CKD)-associated vascular calcification (VC) and the underlying …

Irisin, the circulating peptide originating from fibronectin type III domain-containing protein 5
(FNDC5), is mainly expressed by muscle fibers under peroxisome proliferator-activated …

Irisin is a muscle-secreted hormone that is generated by cleavage of membrane protein
FNDC-5 (fibronectin type III domain-containing protein 5). Irisin is considered to be a …

Background Osteoporosis is recognized as a skeletal disorder characterized by diminished
bone tissue quality and density. Regular physical exercise is widely acknowledged to …

Obesity is associated with biological dysfunction in skeletal muscle. As a condition of obesity
accompanied by muscle mass loss and physical dysfunction, sarcopenic obesity (SO) has …

A sedentary lifestyle or lack of physical activity increases the risk of different diseases,
including obesity, diabetes, heart diseases, certain types of cancers, and some neurological …

Reactive oxygen species (ROS) overproduction promotes the alveolar bone loss during the
development of periodontitis. Mitochondria are the principal source of ROS. Hydroxytyrosol …

Exercise physiology has gained increasing interest due to its wide effects to promote health.
Recent years have seen a growth in this research field also due to the finding of several …