Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

The architecture of neuron connectivity in brain networks is one of the basic mechanisms by
which to organize and sustain a particular function of the brain circuitry. There are areas of …

Microfluidic technology has become a valuable tool to the scientific community, allowing
researchers to study fine cellular mechanisms with higher variable control compared with …

The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …

We discuss several continuum cell-cell adhesion models based on the underlying
microscopic assumptions. We propose an improvement on these models leading to sharp …

Neuronal growth cone filopodia contain guidance receptors and contribute to axon
guidance; however, the mechanism by which the guidance cue netrin increases filopodia …

The neural circuits of the central nervous system are the regulatory pathways for feeling,
motion control, learning, and memory, and their dysfunction is closely related to various …

Appropriate axon guidance is necessary to form accurate neuronal connections. Axon
guidance cues that stimulate cytoskeletal reorganization within the growth cone direct axon …

Neurite elongation and branching in developing neurons requires plasmalemma expansion,
hypothesized to occur primarily via exocytosis. We posited that exocytosis in developing …