With their ever-growing prevalence, obesity and diabetes represent major health threats of
our society. Based on estimations by the World Health Organization, approximately 300 …

In this overview, we discuss the discovery and development of topiramate (TPM) as an
anticonvulsant, including notable aspects of its chemical, biologic, and pharmacokinetic …

Background Topiramate, a sulphamate fructopyranose derivative, might antagonise
alcohol's rewarding effects associated with abuse liability by inhibiting mesocorticolimbic …

The current obesity pandemic results from a physiological imbalance in which energy intake
chronically exceeds energy expenditure (EE), and prevention and treatment strategies …

ContextHypothetically, topiramate can improve drinking outcomes among alcohol-
dependent individuals by reducing alcohol's reinforcing effects through facilitation of γ …

Due to the diverse mechanisms of action of antiseizure drugs, there has been a rise in
prescriptions of these drugs for non-epileptic pathologies. One drug that is now being used …

For many years, obesity was believed to be a condition of overeating that could be resolved
through counseling and short-term drug treatment. Obesity was not recognized as a chronic …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

Abstract The GABA A receptor (GABA AR) is a major target of antiseizure drugs (ASDs). A
variety of agents that act at GABA A Rs s are used to terminate or prevent seizures. Many act …

Carbonic anhydrases (CAs) are a group of ubiquitously expressed metalloenzymes that
catalyze the reversible hydration/dehydration of CO2/HCO3. Thus, they are involved in those …