DNA single-strand break repair and human genetic disease
KW Caldecott - Trends in cell biology, 2022 - cell.com
DNA single-strand breaks (SSBs) are amongst the commonest DNA lesions arising in cells,
with many tens of thousands induced in each cell each day. SSBs arise not only from …
with many tens of thousands induced in each cell each day. SSBs arise not only from …
XRCC1 protein; Form and function
KW Caldecott - DNA repair, 2019 - Elsevier
The human gene that encodes XRCC1 was cloned nearly thirty years ago but experimental
analysis of this fascinating protein is still unveiling new insights into the DNA damage …
analysis of this fascinating protein is still unveiling new insights into the DNA damage …
[HTML][HTML] XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
AA Demin, K Hirota, M Tsuda, M Adamowicz… - Molecular cell, 2021 - cell.com
Mammalian DNA base excision repair (BER) is accelerated by poly (ADP-ribose)
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …
[HTML][HTML] The enigmatic function of PARP1: from PARylation activity to PAR readers
T Kamaletdinova, Z Fanaei-Kahrani, ZQ Wang - Cells, 2019 - mdpi.com
Poly (ADP-ribosyl) ation (PARylation) is catalysed by poly (ADP-ribose) polymerases
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …
[HTML][HTML] The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer
J Rudolph, UM Muthurajan, M Palacio, J Mahadevan… - Molecular cell, 2021 - cell.com
PARP1 is a key player in the response to DNA damage and is the target of clinical inhibitors
for the treatment of cancers. Binding of PARP1 to damaged DNA leads to activation wherein …
for the treatment of cancers. Binding of PARP1 to damaged DNA leads to activation wherein …
Poly (ADP-ribosyl) ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates
Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …
Base excision repair and its implications to cancer therapy
GJ Grundy, JL Parsons - Essays in biochemistry, 2020 - portlandpress.com
Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular
oxidative stress and in response to exogenous insults. The pathway is a coordinated …
oxidative stress and in response to exogenous insults. The pathway is a coordinated …
[HTML][HTML] XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair
M Adamowicz, R Hailstone, AA Demin… - Nature Cell …, 2021 - nature.com
Genetic defects in the repair of DNA single-strand breaks (SSBs) can result in neurological
disease triggered by toxic activity of the single-strand-break sensor protein PARP1 …
disease triggered by toxic activity of the single-strand-break sensor protein PARP1 …
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity
A Serrano‐Benitez, SE Wells… - The EMBO …, 2023 - embopress.org
DNA single‐strand breaks (SSBs) disrupt DNA replication and induce chromosome
breakage. However, whether SSBs induce chromosome breakage when present behind …
breakage. However, whether SSBs induce chromosome breakage when present behind …
[HTML][HTML] The complex mechanisms by which neurons die following DNA damage in neurodegenerative diseases
Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …