The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

The age-associated decline of the neurological and cognitive functions becomes more and
more serious challenge for the developed countries with the increasing number of aged …

Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …

Pericytes are cells in the blood–brain barrier (BBB) that degenerate in A lzheimer's disease
(AD), a neurodegenerative disorder characterized by early neurovascular dysfunction …

The blood-brain barrier (BBB) and blood-cerebrospinal fluid (BCSF) barriers are critical
determinants of CNS homeostasis. Additionally, the BBB and BCSF barriers are formidable …

Alzheimer's disease (AD), the most common neurodegenerative disorder associated with
dementia, is typified by the pathological accumulation of amyloid Aβ peptides and …

Several studies, including genome wide association studies (GWAS), have strongly
suggested a central role for the ATP-binding cassette transporter subfamily A member 7 …

The blood–brain barrier (BBB) tightly controls the molecular exchange between the brain
parenchyma and blood. Accumulated evidence from transgenic animal Alzheimer's disease …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …