Bacteriocins from lactic acid bacteria. A powerful alternative as antimicrobials, probiotics, and immunomodulators in veterinary medicine

JC Hernández-González, A Martínez-Tapia… - Animals, 2021 - mdpi.com
Simple Summary Antibiotic resistance is a growing threat; its indiscriminate use has led to
management restrictions in humans and animals. Bacteriocins are powerful antimicrobial …

Bacteriocin-antimicrobial synergy: a medical and food perspective

H Mathur, D Field, MC Rea, PD Cotter, C Hill… - Frontiers in …, 2017 - frontiersin.org
The continuing emergence of multi-drug resistant pathogens has sparked an interest in
seeking alternative therapeutic options. Antimicrobial combinatorial therapy is one such …

Nisin—A lantibiotic with immunomodulatory properties: A review

J Małaczewska, E Kaczorek-Łukowska - Peptides, 2021 - Elsevier
Nisin, a member of class I bacteriocins known as lantibiotics, is produced by the lactic acid
bacterium Lactococcus lactis and is characterized by a wide spectrum of antibacterial activity …

The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications

G Férir, MI Petrova, G Andrei, D Huskens… - PloS one, 2013 - journals.plos.org
Lantibiotics are peptides, produced by bacteria, that contain the noncanonical amino acid
lanthionine and many of them exhibit antibacterial activities. The labyrinthopeptin A1 …

Probiotics, including nisin‐based probiotics, improve clinical and microbial outcomes relevant to oral and systemic diseases

T Nguyen, H Brody, GH Lin, H Rangé… - Periodontology …, 2020 - Wiley Online Library
The effects of probiotic supplementation on systemic health and gastrointestinal diseases
have been investigated in numerous studies. The aim of this review is to provide an …

Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans

AJ van Heel, M Montalban-Lopez… - Expert opinion on drug …, 2011 - Taylor & Francis
Since the commercialization and ubiquitous use of antibiotics in the 20th century, there has
been a steady increase in the number of reports on resistant bacteria. In recent years, this …

Manipulation of innate immunity by a bacterial secreted peptide: lantibiotic nisin Z is selectively immunomodulatory

J Kindrachuk, H Jenssen, M Elliott, A Nijnik… - Innate …, 2013 - journals.sagepub.com
Innate immunity is triggered by a variety of bacterial molecules, resulting in both protective
and potentially harmful pro-inflammatory responses. Further, innate immunity also provides …

Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis

AA Joshi, M Vocanson, JF Nicolas, P Wolf… - Frontiers in …, 2023 - frontiersin.org
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly
affects the patient's quality of life. A disrupted skin barrier, type 2 cytokine-dominated …

Are bacteriocins underexploited? Novel applications for old antimicrobials

M Montalbán-López… - Current …, 2011 - ingentaconnect.com
Bacteriocins are ribosomally synthesized (poly) peptides produced by almost all prokaryotic
lineages. Bacteriocins from lactic acid bacteria (LAB) and bacteriocin-producer probiotic …

In vitro immunomodulatory effect of nisin on porcine leucocytes

J Małaczewska, E Kaczorek‐Łukowska… - Journal of animal …, 2019 - Wiley Online Library
Nisin, a lantibiotic bacteriocin, has been used for years as a natural food preservative. In
addition to its antimicrobial activity, nisin also shows immunomodulatory properties, and the …