Innate sensing of oxidation-specific epitopes in health and disease
Ageing, infections and inflammation result in oxidative stress that can irreversibly damage
cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of …
cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of …
Recognition of oxidized lipids by macrophages and its role in atherosclerosis development
NV Mushenkova, EE Bezsonov, VA Orekhova… - Biomedicines, 2021 - mdpi.com
Atherosclerosis is a multifactorial chronic disease that has a prominent inflammatory
component. Currently, atherosclerosis is regarded as an active autoimmune process that …
component. Currently, atherosclerosis is regarded as an active autoimmune process that …
[HTML][HTML] Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, with poor
prognosis and no cure. Substantial evidence implicates inflammation and associated …
prognosis and no cure. Substantial evidence implicates inflammation and associated …
Context-dependent role of oxidized lipids and lipoproteins in inflammation
YI Miller, JYJ Shyy - Trends in Endocrinology & Metabolism, 2017 - cell.com
Oxidized low-density lipoprotein (OxLDL), which contains hundreds of different oxidized lipid
molecules, is a hallmark of hyperlipidemia and atherosclerosis. The same oxidized lipids …
molecules, is a hallmark of hyperlipidemia and atherosclerosis. The same oxidized lipids …
Bioactive metabolites of docosahexaenoic acid
O Kuda - Biochimie, 2017 - Elsevier
Docosahexaenoic acid (DHA) is an essential fatty acid that is recognized as a beneficial
dietary constituent and as a source of the anti-inflammatory specialized proresolving …
dietary constituent and as a source of the anti-inflammatory specialized proresolving …
Investigational drugs in clinical trials for macular degeneration
MJ Tolentino, AJ Tolentino - Expert Opinion on Investigational …, 2022 - Taylor & Francis
Introduction Intravitreal anti-vascular endothelial growth factor (VEGF) injections for
exudative age-related macular degeneration (eAMD) are effective and safe but require …
exudative age-related macular degeneration (eAMD) are effective and safe but require …
[HTML][HTML] Oxidized lipids: common immunogenic drivers of non-alcoholic fatty liver disease and atherosclerosis
The prevalence of non-alcoholic fatty liver disease (NAFLD), ranging from simple steatosis
to inflammatory steatohepatitis (NASH) and cirrhosis, continues to rise, making it one of the …
to inflammatory steatohepatitis (NASH) and cirrhosis, continues to rise, making it one of the …
TLR2 plays a key role in platelet hyperreactivity and accelerated thrombosis associated with hyperlipidemia
Rationale: Platelet hyperreactivity, which is common in many pathological conditions, is
associated with increased atherothrombotic risk. The mechanisms leading to platelet …
associated with increased atherothrombotic risk. The mechanisms leading to platelet …
Oxidative modifications of extracellular matrix promote the second wave of inflammation via β2 integrins
VP Yakubenko, K Cui, CL Ardell… - Blood, The Journal …, 2018 - ashpublications.org
Early stages of inflammation are characterized by extensive oxidative insult by recruited and
activated neutrophils. Secretion of peroxidases, including the main enzyme …
activated neutrophils. Secretion of peroxidases, including the main enzyme …
Chemistry and biology of ω-3 PUFA peroxidation-derived compounds
The ω-3 polyunsaturated fatty acids (PUFAs) are among the most popular dietary
supplements in the US, but they are chemically unstable and highly prone to lipid …
supplements in the US, but they are chemically unstable and highly prone to lipid …