Innate sensing of oxidation-specific epitopes in health and disease

CJ Binder, N Papac-Milicevic, JL Witztum - Nature Reviews …, 2016 - nature.com
Ageing, infections and inflammation result in oxidative stress that can irreversibly damage
cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of …

Recognition of oxidized lipids by macrophages and its role in atherosclerosis development

NV Mushenkova, EE Bezsonov, VA Orekhova… - Biomedicines, 2021 - mdpi.com
Atherosclerosis is a multifactorial chronic disease that has a prominent inflammatory
component. Currently, atherosclerosis is regarded as an active autoimmune process that …

[HTML][HTML] Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis

L Xiong, M McCoy, H Komuro, XZ West… - Free Radical Biology …, 2022 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, with poor
prognosis and no cure. Substantial evidence implicates inflammation and associated …

Context-dependent role of oxidized lipids and lipoproteins in inflammation

YI Miller, JYJ Shyy - Trends in Endocrinology & Metabolism, 2017 - cell.com
Oxidized low-density lipoprotein (OxLDL), which contains hundreds of different oxidized lipid
molecules, is a hallmark of hyperlipidemia and atherosclerosis. The same oxidized lipids …

Bioactive metabolites of docosahexaenoic acid

O Kuda - Biochimie, 2017 - Elsevier
Docosahexaenoic acid (DHA) is an essential fatty acid that is recognized as a beneficial
dietary constituent and as a source of the anti-inflammatory specialized proresolving …

Investigational drugs in clinical trials for macular degeneration

MJ Tolentino, AJ Tolentino - Expert Opinion on Investigational …, 2022 - Taylor & Francis
Introduction Intravitreal anti-vascular endothelial growth factor (VEGF) injections for
exudative age-related macular degeneration (eAMD) are effective and safe but require …

[HTML][HTML] Oxidized lipids: common immunogenic drivers of non-alcoholic fatty liver disease and atherosclerosis

C Hoebinger, D Rajcic, T Hendrikx - Frontiers in cardiovascular …, 2022 - frontiersin.org
The prevalence of non-alcoholic fatty liver disease (NAFLD), ranging from simple steatosis
to inflammatory steatohepatitis (NASH) and cirrhosis, continues to rise, making it one of the …

TLR2 plays a key role in platelet hyperreactivity and accelerated thrombosis associated with hyperlipidemia

S Biswas, A Zimman, D Gao, TV Byzova… - Circulation …, 2017 - Am Heart Assoc
Rationale: Platelet hyperreactivity, which is common in many pathological conditions, is
associated with increased atherothrombotic risk. The mechanisms leading to platelet …

Oxidative modifications of extracellular matrix promote the second wave of inflammation via β2 integrins

VP Yakubenko, K Cui, CL Ardell… - Blood, The Journal …, 2018 - ashpublications.org
Early stages of inflammation are characterized by extensive oxidative insult by recruited and
activated neutrophils. Secretion of peroxidases, including the main enzyme …

Chemistry and biology of ω-3 PUFA peroxidation-derived compounds

W Wang, H Yang, D Johnson, C Gensler… - Prostaglandins & other …, 2017 - Elsevier
The ω-3 polyunsaturated fatty acids (PUFAs) are among the most popular dietary
supplements in the US, but they are chemically unstable and highly prone to lipid …