Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation
in asthma and chronic obstructive pulmonary disease (COPD), making them attractive …

Primary eosinophilic gastrointestinal disorders are defined as disorders that selectively
affect the gastrointestinal tract with eosinophil-rich inflammation in the absence of known …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic
adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from …

Introduction: Chemokines play important roles in inflammation and in immune responses.
This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and …

Chemokines are the largest family of cytokines in human immunophysiology. These proteins
are defined by four invariant cysteines and are categorized based on the sequence around …

G protein-coupled receptors (GPCRs) represent the largest family of cell-surface receptors.
These receptors are natural allosteric proteins because agonist-mediated signaling by …

Cell-surface receptors are the targets for more than 60% of current drugs. Traditionally,
optimizing the interaction of lead molecules with the binding site for the endogenous agonist …

Chemokines and their receptors are involved in the pathogenesis of diseases ranging from
asthma to AIDS. Chemokine receptors are G-protein-coupled serpentine receptors that …

Blood eosinophilia and tissue eosinophilia are characteristic features of allergic
inflammation and asthma, conditions associated with prominent production of TH2 cytokines …