Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …

Parasitic helminths release molecules into their environment, which are generally referred to
as excretory-secretory products or ES. ES derived from a wide range of nematodes …

Schistosomiasis is a neglected tropical disease caused by blood flukes (genus
Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are …

Parasitic diseases have a devastating, long-term impact on human health, welfare and food
production worldwide. More than two billion people are infected with geohelminths …

Lymphatic filariasis (LF) is a socio-economically devastating mosquito-borne Neglected
Tropical Disease caused by parasitic filarial nematodes. The interaction between the …

BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …

The hunt for effective vaccines against the major helminth diseases of humans has yet to
bear fruit despite much effort over several decades. No individual parasite antigen has …

Ivermectin (IVM) is a broad-spectrum anthelmintic used in filariasis control programs. By
binding to nematode glutamate-gated chloride channels (GluCls), IVM disrupts …

Human disease caused by parasitic filarial nematodes is a major cause of global morbidity.
The parasites are transmitted by arthropod intermediate hosts and are responsible for …

The discovery of Wolbachia intracellular bacteria within filarial nematodes, including
Onchocerca volvulus, the causative agent of onchocerciasis or “river blindness,” has …