[HTML][HTML] Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity
Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …
Secretory products of helminth parasites as immunomodulators
W Harnett - Molecular and biochemical parasitology, 2014 - Elsevier
Parasitic helminths release molecules into their environment, which are generally referred to
as excretory-secretory products or ES. ES derived from a wide range of nematodes …
as excretory-secretory products or ES. ES derived from a wide range of nematodes …
[HTML][HTML] Whole-genome sequence of Schistosoma haematobium
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus
Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are …
Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are …
[HTML][HTML] Ascaris suum draft genome
Parasitic diseases have a devastating, long-term impact on human health, welfare and food
production worldwide. More than two billion people are infected with geohelminths …
production worldwide. More than two billion people are infected with geohelminths …
[HTML][HTML] Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi
Lymphatic filariasis (LF) is a socio-economically devastating mosquito-borne Neglected
Tropical Disease caused by parasitic filarial nematodes. The interaction between the …
Tropical Disease caused by parasitic filarial nematodes. The interaction between the …
Glutathione and infection
BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …
demonstrated protective abilities against the detrimental effects of oxidative stress within the …
[HTML][HTML] Extracellular vesicles: new targets for vaccines against helminth parasites
C Drurey, G Coakley, RM Maizels - International Journal for Parasitology, 2020 - Elsevier
The hunt for effective vaccines against the major helminth diseases of humans has yet to
bear fruit despite much effort over several decades. No individual parasite antigen has …
bear fruit despite much effort over several decades. No individual parasite antigen has …
Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi
Y Moreno, JF Nabhan, J Solomon… - Proceedings of the …, 2010 - National Acad Sciences
Ivermectin (IVM) is a broad-spectrum anthelmintic used in filariasis control programs. By
binding to nematode glutamate-gated chloride channels (GluCls), IVM disrupts …
binding to nematode glutamate-gated chloride channels (GluCls), IVM disrupts …
[HTML][HTML] The Wolbachia endosymbiont as an anti-filarial nematode target
BE Slatko, MJ Taylor, JM Foster - Symbiosis, 2010 - Springer
Human disease caused by parasitic filarial nematodes is a major cause of global morbidity.
The parasites are transmitted by arthropod intermediate hosts and are responsible for …
The parasites are transmitted by arthropod intermediate hosts and are responsible for …
Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment
F Tamarozzi, A Halliday, K Gentil… - Clinical microbiology …, 2011 - Am Soc Microbiol
The discovery of Wolbachia intracellular bacteria within filarial nematodes, including
Onchocerca volvulus, the causative agent of onchocerciasis or “river blindness,” has …
Onchocerca volvulus, the causative agent of onchocerciasis or “river blindness,” has …