In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents
the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet …

Background: Patients with substantive bleeding usually require transfusion and/or (re-)
operation. Red blood cell (RBC) transfusion is independently associated with a greater risk …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Platelets play a fundamental role in normal hemostasis, while their inherited or acquired
dysfunctions are involved in a variety of bleeding disorders or thrombotic events. Several …

FOR MAJOR BLEEDING related to severe trauma, major surgery, or chronic anticoagulation,
a rapid assessment of hemostatic function is crucial so that optimal fluid replacements and …

The two most widely used antiplatelet drugs in the world are aspirin and clopidogrel.
However, some patients on aspirin and/or clopidogrel therapy do not respond appropriately …

Perioperative coagulation monitoring is the rational diagnostic basis for pro-and anti-
thrombotic interventions in patients undergoing emergency and elective surgery. The main …

Aspirin is one of the cornerstones of treatment for cardiovascular disease. However, some
patients may be 'resistant'to its effect: this is associated with adverse cardiovascular …

Clopidogrel low-responsiveness assessed with multiple electrode platelet aggregometry
(MEA) has been shown to be a strong and independent predictor of early stent thrombosis …

Dual antiplatelet therapy of aspirin and clopidogrel is pivotal for patients undergoing
percutaneous coronary intervention. However, the variable platelets reactivity response to …