Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …

Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …

One-third of the world's population infected tuberculosis (TB), and more than 1 million
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …

Arylamine N‐acetyltransferases (NAT s) are polymorphic drug‐metabolizing enzymes,
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …

Mycolic acids are the major lipid components of the unique mycobacterial cell wall
responsible for the protection of the tuberculosis bacilli from many outside threats. Mycolic …

Tuberculosis (TB), although a curable disease, is still one of the most difficult infections to
treat. Mycobacterium tuberculosis infects 10 million people worldwide and kills 1.5 million …

Abstract Various substituted 4, 6-diarylpyrimidin-2-amine (4), 4, 6-diaryl-2-(heteroaryl)
pyrimidine (6) and 1-(3, 5-diaryl-4, 5-dihydro-1H-pyrazol-1-yl) ethanone (7) derivatives were …

Pyrazole is an imperative heterocyclic molecule in the synthetic and medicinal fields.
Pyrazole is stable compound that is particularly used in pharmaceutical applications (ie …

Chagas disease, also known as American trypanosomiasis, is classified as a neglected
disease by the World Health Organization. For clinical treatment, only two drugs have been …

Arylamine N-acetyltransferase from Mycobacterium tuberculosis (TBNAT) plays an important
role in the intracellular survival of the microorganism inside macrophages. Medicinal …