The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …

The E2F transcription factor family determines whether or not a cell will divide by controlling
the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct …

The retinoblastoma gene was identified over a decade ago as the first tumor suppressor.
Although the gene was initially cloned as a result of its frequent mutation in the rare pediatric …

Cardiac myocytes rapidly proliferate during fetal life but exit the cell cycle soon after birth in
mammals. Although the extent to which adult cardiac myocytes are capable of cell cycle …

Approximately 200 human papillomaviruses (HPVs) infect human epithelial cells, of which
the alpha and beta types have been the most extensively studied. Alpha HPV types mainly …

A key event in the regulation of eukaryotic gene expression is the posttranslational
modification of nucleosomal histones, which converts regions of chromosomes into …

E2F transcription activity is composed of a family of heterodimers encoded by distinct genes.
Through the overproduction of each of the five known E2F proteins in mammalian cells, we …

The retinoblastoma (RB) family of proteins are found in organisms as distantly related as
humans, plants, and insects. These proteins play a key role in regulating advancement of …