[HTML][HTML] Tumoral heterogeneity in neuroblastoma
RL Gomez, S Ibragimova, R Ramachandran… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …
[HTML][HTML] Plasticity in neuroblastoma cell identity defines a noradrenergic-to-mesenchymal transition (NMT)
M Gautier, C Thirant, O Delattre, I Janoueix-Lerosey - Cancers, 2021 - mdpi.com
Simple Summary Neuroblastoma arises in the developing sympathetic nervous system and
represents the most common extracranial pediatric solid tumor. High-risk patients often …
represents the most common extracranial pediatric solid tumor. High-risk patients often …
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin
Abstract Characterization of the progression of cellular states during human embryogenesis
can provide insights into the origin of pediatric diseases. We examined the transcriptional …
can provide insights into the origin of pediatric diseases. We examined the transcriptional …
[HTML][HTML] The immune cell atlas of human neuroblastoma
BM Verhoeven, S Mei, TK Olsen, K Gustafsson… - Cell Reports …, 2022 - cell.com
Understanding the complete immune cell composition of human neuroblastoma (NB) is
crucial for the development of immunotherapeutics. Here, we perform single-cell RNA …
crucial for the development of immunotherapeutics. Here, we perform single-cell RNA …
Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance
Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB). Here,
we developed a clinically relevant in vivo treatment protocol mimicking the first-line five …
we developed a clinically relevant in vivo treatment protocol mimicking the first-line five …
Mesenchymal-type neuroblastoma cells escape ALK inhibitors
EM Westerhout, M Hamdi, P Stroeken… - Cancer research, 2022 - AACR
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include
phenotypically immature tumor cells, which have been implicated in therapy resistance …
phenotypically immature tumor cells, which have been implicated in therapy resistance …
Impact of Genomic and Clinical Factors on Outcome of Children ≥18 Months of Age with Stage 3 Neuroblastoma with Unfavorable Histology and without MYCN …
Purpose: Patients≥ 18 months of age with International Neuroblastoma Staging System
(INSS) stage 3 unfavorable histology (UH), MYCN-nonamplified (MYCN-NA) tumors have …
(INSS) stage 3 unfavorable histology (UH), MYCN-nonamplified (MYCN-NA) tumors have …
[HTML][HTML] A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity
Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage
with complex inter-and intra-tumoral heterogeneity. To chart this complexity, we generated a …
with complex inter-and intra-tumoral heterogeneity. To chart this complexity, we generated a …
[HTML][HTML] Unraveling the enigmatic origin of neuroblastoma
Z Liu, CJ Thiele - Cancer Cell, 2020 - cell.com
The cell of origin of neuroblastoma is mysterious due to the complexity of neural crest
derivatives. In this issue of Cancer Cell, Dong et al. compare the transcriptomes of human …
derivatives. In this issue of Cancer Cell, Dong et al. compare the transcriptomes of human …
The Neuroblastoma Microenvironment, Heterogeneity and Immunotherapeutic Approaches
PA Polychronopoulos, OC Bedoya-Reina, JI Johnsen - Cancers, 2024 - mdpi.com
Simple Summary Neuroblastoma, a cancer of the peripheral nervous system, is the most
common and deadly tumor that occurs in childhood. In order to cure more patients with …
common and deadly tumor that occurs in childhood. In order to cure more patients with …