Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

Fluorescent probes have gained profound use in biotechnology, drug discovery, medical
diagnostics, molecular and cell biology. The development of methods for the translation of …

Histone deacetylase (HDAC)‐targeted probes and prodrugs are crucial for cancer
theranostics. We developed a self‐immolative design that enables in vivo activatable near …

Photoaffinity labeling (PAL) in combination with a chemical probe to covalently bind its target
upon UV irradiation has demonstrated considerable promise in drug discovery for identifying …

An anthracene carboxyimide derivative was synthesized as a colorimetric and fluorogenic
sensor to determine NO2− with a rapid response (< 4 min), excellent selectivity and a low …

The elucidation of substrate–protein interactions is an important component of the drug
development process. Due to the complexity of native cellular environments, elucidating …

Comprehensive Summary Since the advent of fluorescent probes, they have been widely
used in the field of life sciences. Fluorescent probes can not only light up the cells, tissues …

Covalent modifications of DNA and histones are key cellular epigenetic marks to regulate
gene functions. Most of these epigenetic marks are added or removed by corresponding …

Lysine acylation plays pivotal roles in cell physiology, including DNA transcription and
repair, signal transduction, immune defense, metabolism, and many other key cellular …